Evidence map›Paper›PMID 25087623›Full record

ReviewMicrovascular research2014

Lymphangiogenesis and metastasis--a closer look at the neuropilin/semaphorin3 axis.

Matthew T Migliozzi, Patrick Mucka, Diane R Bielenberg

Abstract readReview
In one paragraph

Review in Microvascular research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. ZebrafishZebrafish · 2023
    Article
  2. Neuropilins in the Context of Tumor Vasculature.International journal of molecular sciences · 2019
    Review
  3. Review
  4. Article
  5. Article
  6. The role of EMT and MET in cancer dissemination.Connective tissue research · 2015
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Matthew T MigliozziVascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.
Patrick MuckaVascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.
Diane R BielenbergVascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, MA 02115, USA. Electronic address: diane.bielenberg@childrens.harvard.edu.

Funding

Semaphorin 3F: Structure, Function, and Anti-Metastatic ActivityK01CA118732 · NCI · BOSTON CHILDREN'S HOSPITAL · PI BIELENBERG, DIANE RENEE · 2006 to 2010
$774k
Targeting Neuropilin 2 with Semaphorin 3F during Pancreatic Carcinoma ProgressionR21CA155728 · NCI · BOSTON CHILDREN'S HOSPITAL · PI BIELENBERG, DIANE RENEE · 2011 to 2012
$416k
NCI NIH HHS K01 CA118732NCI NIH HHS K01CA118732NCI NIH HHS R21 CA155728NCI NIH HHS R21CA155728
6 · The paper itself

Abstract

Metastasis is the leading cause of cancer-related deaths. Understanding how the lymphatic system responds to its environment and local stimuli may lead to therapies to combat metastasis and other lymphatic-associated diseases. This review compares lymphatic vessels and blood vessels, discusses markers of lymphatic vasculature, and elucidates some of the signaling motifs involved in lymphangiogenesis. Recent progress implicating the neuropilin and semaphorin axes in this process is discussed.

Indexed as

AnimalsHumansLymphangiogenesisLymphatic MetastasisLymphatic SystemLymphatic VesselsMiceMice, Inbred BALB CMice, TransgenicMutationNeoplasm MetastasisNeoplasmsNeuropilinsSemaphorin-3ASignal TransductionNeuropilinsSema3a protein, mouseSemaphorin-3ACancerLymphangiogenesisMetastasisNeuropilinSemaphorin

Identifiers

PMID25087623
PMCPMC4268048

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.