ArticleNeurobiology of aging2015
Spatial reference memory in normal aging Fischer 344 × Brown Norway F1 hybrid rats.
Article in Neurobiology of aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of aging on animal models of Parkinson's disease.Frontiers in aging neuroscience · 2022Pooled it
- A Parallelized, Automated System for Higher-Throughput Spatial Navigation Testing of Rats.eNeuro · 2026Article
- Biological sex and normative cognitive aging across spatial learning, flexibility, and working memory in Fischer 344 rats.Behavioral neuroscience · 2026Article
- Bone microarchitecture and material properties decline differently across midlife for male and female F344 × BN F1 rats.bioRxiv : the preprint server for biology · 2026Article
- Stereological sampling-based estimates of dopaminergic and cholinergic neuron numbers in young adult and aged male and female Fischer 344 × Brown Norway F1 hybrid rats.Frontiers in aging neuroscience · 2026Article
- A Parallelized, Automated System for Higher-Throughput Spatial Navigation Testing of Rats.bioRxiv : the preprint server for biology · 2025Article
- Age-related synaptic signatures of brain and cognitive reserve in the rat hippocampus and parahippocampal regions.Neurobiology of aging · 2025Article
- Intermittent working memory training during adulthood protects against age-related long-term spatial reference memory decline in rats.GeroScience · 2024Article
- Daily fluctuations in blood glucose with normal aging are inversely related to hippocampal synaptic mitochondrial proteins.Aging brain · 2024Article
- A long-term ketogenic diet in young and aged rats has dissociable effects on prelimbic cortex and CA3 ensemble activity.Frontiers in aging neuroscience · 2023Article
- 'Arc'-hitecture of normal cognitive aging.Ageing research reviews · 2022Review
- Attenuated NMDAR signaling on fast-spiking interneurons in prefrontal cortex contributes to age-related decline of cognitive flexibility.Neuropharmacology · 2021Article
- Sex and Age Effects on Neurobehavioral Toxicity Induced by Binge Alcohol.Brain plasticity (Amsterdam, Netherlands) · 2020Review
- Sex differences in age-related impairments vary across cognitive and physical assessments in rats.Behavioral neuroscience · 2020Article
- Loss of NRF2 leads to impaired mitochondrial function, decreased synaptic density and exacerbated age-related cognitive deficits.Experimental gerontology · 2020Article
- Age-Related Alterations in Prelimbic Cortical NeuronFrontiers in aging neuroscience · 2020Article
- A Cross-species Model of Dual-Task Walking in Young and Older Humans and Rats.Frontiers in aging neuroscience · 2020Article
- Age-Induced Spatial Memory Deficits in Rats Are Correlated with Specific Brain Region Alterations in Microglial Morphology and Gene Expression.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019Article
- Structural and molecular correlates of cognitive aging in the rat.Scientific reports · 2019Article
- Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity.Neurobiology of aging · 2018Article
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2 authors.
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Abstract
Fischer 344 × Brown Norway F1 (F344 × BN-F1) hybrid rats express greater longevity with improved health relative to aging rodents of other strains; however, few behavioral reports have thoroughly evaluated cognition across the F344 × BN-F1 lifespan. Consequently, this study evaluated spatial reference memory in F344 × BN-F1 rats at 6, 18, 24, or 28 months of age in the Morris water maze. Reference memory decrements were observed between 6 and 18 months and 18 and 24 months. At 28 months, spatial learning was not worse than 24 months, but swim speed was significantly slower. Reliable individual differences revealed that ∼50% of 24- to 28-month-old rats performed similarly to 6 months, whereas others were spatial learning impaired. Aged rats were impaired at learning within daily training sessions but not impaired at retaining information between days of training. Aged rats were also slower to learn to escape onto the platform, regardless of strategy. In summary, these data clarify the trajectory of cognitive decline in aging F344 × BN-F1 rats and elucidate relevant behavioral parameters.
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