Evidence map›Paper›PMID 25086816›Full record

ArticleHeart and vessels2015

The effects of weight gain after smoking cessation on atherogenic α1-antitrypsin-low-density lipoprotein.

Maki Komiyama, Hiromichi Wada, Shuichi Ura, Hajime Yamakage, Noriko Satoh-Asahara, Sayaka Shimada, Masaharu Akao, Hiroshi Koyama, Koichi Kono, Akira Shimatsu and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Heart and vessels, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Alpha1-Antitrypsin in Lung Diseases: A Cross-Sectional Observational Study.International journal of molecular sciences · 2025
    Observational
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Post-Translational Modifications of Circulating Alpha-1-Antitrypsin Protein.International journal of molecular sciences · 2020
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Curcumin May (Not) Defy Science.ACS medicinal chemistry letters · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Maki KomiyamaDepartment of General Internal Medicine, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Hiromichi WadaDivision of Translational Research, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto, 612-8555, Japan.
Shuichi UraDivision of Translational Research, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto, 612-8555, Japan.
Hajime YamakageClinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Noriko Satoh-AsaharaClinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Sayaka ShimadaDivision of Translational Research, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto, 612-8555, Japan.
Masaharu AkaoDepartment of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Hiroshi KoyamaDepartment of General Internal Medicine, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Koichi KonoDepartment of Hygiene and Public Health, Osaka Medical College, Osaka, Japan.
Akira ShimatsuClinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Yuko TakahashiHealth Care Center, Nara Women's University, Nara, Japan.
Koji HasegawaDivision of Translational Research, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto, 612-8555, Japan. koj@kuhp.kyoto-u.ac.jp.
Kyoto Medical Center · JPOsaka Medical and Pharmaceutical University · JPNara Women's University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although cardiovascular risks decrease after quitting smoking, body weight often increases in the early period after smoking cessation. We have previously reported that the serum level of the α1-antitrypsin-low-density lipoprotein complex (AT-LDL)-an oxidatively modified low-density lipoprotein that accelerates atherosclerosis-is high in current smokers, and that the level rapidly decreases after smoking cessation. However, the effects of weight gain after smoking cessation on this cardiovascular marker are unknown. In 183 outpatients (134 males, 49 females) who had successfully quit smoking, serum AT-LDL levels were measured using an enzyme-linked immunosorbent assay. For all persons who had successfully quit smoking, body mass index (BMI) significantly increased 12 weeks after the first examination (p < 0.01). Among patients with a BMI increase smaller than the median, a significant decrease (p < 0.01) in serum AT-LDL values was found, but no significant changes in serum AT-LDL values were found in patients with a BMI increase greater than the median. The findings suggest that the decrease in serum AT-LDL levels after quitting smoking is influenced by weight gain after smoking cessation.

Indexed as

Weight GainAdultAgedAged, 80 and overalpha 1-AntitrypsinAtherosclerosisBiomarkersBody Mass IndexFemaleHumansJapanLipoproteins, LDLMaleMiddle AgedRetrospective StudiesSmokingalpha 1-AntitrypsinBiomarkersLipoproteins, LDLAtherosclerosisObesityOxiditive stresssPreventionSmoking cessation

Identifiers

PMID25086816
PMCPMC4648963
OpenAlexW2075854819

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.