ArticleNature neuroscience2014
An olfactory cocktail party: figure-ground segregation of odorants in rodents.
Article in Nature neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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Who cites it
89 citing papers in PubMed.
- Perception and neural representation of intermittent odor stimuli in mice.Nature communications · 2026Article
- Convergent motifs of early olfactory processing are recapitulated by layer-wise efficient coding.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Investigation of the Impact of Extraneous Odours on the Detection Capability of Explosive Detection Dogs Under a Controlled Test Environment.Animals : an open access journal from MDPI · 2026Article
- Sparse input representations explain odor discrimination in complex, concentration-varying mixtures.bioRxiv : the preprint server for biology · 2026Article
- Glutamatergic Heterogeneity in the Neuropeptide Projections From the Lateral Hypothalamus to the Mouse Olfactory Bulb.The Journal of comparative neurology · 2026Article
- Stable olfactory receptor activation across odor complexity.iScience · 2025Article
- Simultaneous detection and estimation in olfactory sensing.bioRxiv : the preprint server for biology · 2025Article
- Odor Experience Stabilizes Glomerular Output Representations in Two Mouse Models of Autism.eNeuro · 2025Article
- Convergent motifs of early olfactory processing are recapitulated by layer-wise efficient coding.bioRxiv : the preprint server for biology · 2025Article
- Adaptive algorithms for shaping behavior.PLoS computational biology · 2025Article
- Article
- Olfactory dysfunction and altered cortical excitability in the mouse model of Fragile X Syndrome.Biological research · 2025Article
- Recalibrating Olfactory Neuroscience to the Range of Naturally Occurring Odor Concentrations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Detection of odorants in odour mixtures among healthy people and patients with olfactory dysfunction.The European journal of neuroscience · 2025Article
- Behavioral Assays in the Study of Olfaction.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Perceptual constancy for an odor is acquired through changes in primary sensory neurons.Science advances · 2024Article
- Role of Odor Novelty on Olfactory Issues in Autism Spectrum Disorder.Genes, brain, and behavior · 2024Review
- High-speed odor sensing using miniaturized electronic nose.Science advances · 2024Article
- Imaging different cell populations in the mouse olfactory bulb using the genetically encoded voltage indicator ArcLight.Neurophotonics · 2024Review
- Distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortex.Nature communications · 2024Article
29 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
In odorant-rich environments, animals must be able to detect specific odorants of interest against variable backgrounds. However, studies have found that both humans and rodents are poor at analyzing the components of odorant mixtures, suggesting that olfaction is a synthetic sense in which mixtures are perceived holistically. We found that mice could be easily trained to detect target odorants embedded in unpredictable and variable mixtures. To relate the behavioral performance to neural representation, we imaged the responses of olfactory bulb glomeruli to individual odors in mice expressing the Ca(2+) indicator GCaMP3 in olfactory receptor neurons. The difficulty of segregating the target from the background depended strongly on the extent of overlap between the glomerular responses to target and background odors. Our study indicates that the olfactory system has powerful analytic abilities that are constrained by the limits of combinatorial neural representation of odorants at the level of the olfactory receptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.