ArticleNature nanotechnology2014
Remote control of myosin and kinesin motors using light-activated gearshifting.
Article in Nature nanotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed.
- Spatial Activity Patterning and Topological Defect Transport in Acoustically Energized Active Liquid Crystals.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Engineering filamentous myosins for optical control of contractility.bioRxiv : the preprint server for biology · 2025Article
- Illuminating active matter by harnessing light for modular flow control.Nature materials · 2025Article
- Autonomous Nucleic Acid and Protein Nanocomputing Agents Engineered to Operate in Living Cells.ACS nano · 2025Review
- Motility of an autonomous protein-based artificial motor that operates via a burnt-bridge principle.Nature communications · 2024Article
- Spontaneous flows and quantum analogies in heterogeneous active nematic films.Communications physics · 2024Article
- Design of allosteric sites into rotary motor VNature chemistry · 2023Article
- Exploitation of Engineered Light-Switchable Myosin XI for Nanotechnological Applications.ACS nano · 2023Article
- A unified model for the dynamics of ATP-independent ultrafast contraction.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Virus-free transfection, transient expression, and purification of human cardiac myosin in mammalian muscle cells for biochemical and biophysical assays.Scientific reports · 2023Article
- LOV2-based photoactivatable CaMKII and its application to single synapses: Local Optogenetics.Biophysics and physicobiology · 2023Article
- Surface-limited reactions for spatial control of kinesin-microtubule motility assays using indirect irradiation of an electron beam.Biomicrofluidics · 2022Article
- Optophysiology: Illuminating cell physiology with optogenetics.Physiological reviews · 2022Review
- Logic operations with active topological defects.Science advances · 2022Article
- Comprehensive Effects ofFrontiers in plant science · 2022Article
- Protein Based Biomaterials for Therapeutic and Diagnostic Applications.Progress in biomedical engineering (Bristol, England) · 2022Article
- A printable active network actuator built from an engineered biomolecular motor.Nature materials · 2021Article
- Muscle on demand.Nature materials · 2021Article
- Optobiochemistry: Genetically Encoded Control of Protein Activity by Light.Annual review of biochemistry · 2021Review
- Optical control of fast and processive engineered myosins in vitro and in living cells.Nature chemical biology · 2021Article
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6 authors.
Funding
Abstract
Cytoskeletal motors perform critical force generation and transport functions in eukaryotic cells. Engineered modifications of motor function provide direct tests of protein structure-function relationships and potential tools for controlling cellular processes or for harnessing molecular transport in artificial systems. Here, we report the design and characterization of a panel of cytoskeletal motors that reversibly change gears--speed up, slow down or switch directions--when exposed to blue light. Our genetically encoded structural designs incorporate a photoactive protein domain to enable light-dependent conformational changes in an engineered lever arm. Using in vitro motility assays, we demonstrate robust spatiotemporal control over motor function and characterize the kinetics of the optical gearshifting mechanism. We have used a modular approach to create optical gearshifting motors for both actin-based and microtubule-based transport.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.