ArticleBMC medical imaging2014
Diffusion-weighted MRI characteristics of the cerebral metastasis to brain boundary predicts patient outcomes.
Article in BMC medical imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Value of DWI Combined with Magnetic Resonance Spectroscopy in the Differential Diagnosis between Recurrent Glioma and Radiation Injury: A Meta-Analysis.International journal of clinical practice · 2022Pooled it
- Detectability of radiation-induced changes in magnetic resonance biomarkers following stereotactic radiosurgery: A pilot study.PloS one · 2018Trial
- Radiomics for risk stratification in brain metastases: potential in melanoma brain metastases.Clinical & experimental metastasis · 2026Article
- Brain metastases from ovarian cancer: neuroradiological profile and survival overview of neurosurgical cases.Journal of neuro-oncology · 2025Observational
- Radiosurgery for Brain Metastases: Challenges in Imaging Interpretation after Treatment.Cancers · 2023Review
- The relationship of T2 hypointensity and diffusion restriction of brain metastases with the presence and amount of vasogenic edema in MRI.The neuroradiology journal · 2023Article
- Diffusion Weighted Imaging in Neuro-Oncology: Diagnosis, Post-Treatment Changes, and Advanced Sequences-An Updated Review.Cancers · 2023Review
- Metastatic Lesions of the Brain and Spine.Advances in experimental medicine and biology · 2023Article
- Prognostication of overall survival in patients with brain metastases using diffusion tensor imaging and dynamic susceptibility contrast-enhanced MRI.The British journal of radiology · 2022Article
- Advanced MRI to differentiate schwannomas and metastases in the cerebellopontine angle/internal auditory canal.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- Role of apparent diffusion coefficient measurement in differentiating histological subtypes of brain metastasis of lung cancer.Revista da Associacao Medica Brasileira (1992) · 2022Article
- Diffusion Tensor Imaging Can Discriminate the Primary Cell Type of Intracranial Metastases for Patients with Lung Cancer.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Article
- VCAM-1-targeted MRI Improves Detection of the Tumor-brain Interface.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022Article
- ADC textural features in patients with single brain metastases improve clinical risk models.Clinical & experimental metastasis · 2022Article
- Article
- Biological implications and clinical potential of invasion and migration related miRNAs in glioma.Frontiers in integrative neuroscience · 2022Review
- Multiparametric MR Imaging Features of Primary CNS Lymphomas.Frontiers in surgery · 2022Article
- Distinct tumor signatures using deep learning-based characterization of the peritumoral microenvironment in glioblastomas and brain metastases.Scientific reports · 2021Article
- Differentiation of brain metastases from small and non-small lung cancers using apparent diffusion coefficient (ADC) maps.BMC medical imaging · 2021Article
- The Role of the Immune Response in Brain Metastases: Novel Imaging Biomarkers for Immunotherapy.Frontiers in oncology · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDiffusion-weighted MRI (DWI) has been used in neurosurgical practice mainly to distinguish cerebral metastases from abscess and glioma. There is evidence from other solid organ cancers and metastases that DWI may be used as a biomarker of prognosis and treatment response. We therefore investigated DWI characteristics of cerebral metastases and their peritumoral region recorded pre-operatively and related these to patient outcomes.
methodsRetrospective analysis of 76 cases operated upon at a single institution with DWI performed pre-operatively at 1.5T. Maps of apparent diffusion coefficient (ADC) were generated using standard protocols. Readings were taken from the tumor, peritumoral region and across the brain-tumor interface. Patient outcomes were overall survival and time to local recurrence.
resultsA minimum ADC greater than 919.4 × 10(-6) mm(2)/s within a metastasis predicted longer overall survival regardless of adjuvant therapies. This was not simply due to differences between the types of primary cancer because the effect was observed even in a subgroup of 36 patients with the same primary, non-small cell lung cancer. The change in diffusion across the tumor border and into peritumoral brain was measured by the "ADC transition coefficient" or ATC and this was more strongly predictive than ADC readings alone. Metastases with a sharp change in diffusion across their border (ATC >0.279) showed shorter overall survival compared to those with a more diffuse edge. The ATC was the only imaging measurement which independently predicted overall survival in multivariate analysis (hazard ratio 0.54, 95% CI 0.3 - 0.97, p = 0.04).
conclusionsDWI demonstrates changes in the tumor, across the tumor edge and in the peritumoral region which may not be visible on conventional MRI and this may be useful in predicting patient outcomes for operated cerebral metastases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.