Evidence map›Paper›PMID 25086498›Full record

ArticleVirology2014

Human borna disease virus infection impacts host proteome and histone lysine acetylation in human oligodendroglia cells.

Xia Liu, Libo Zhao, Yongtao Yang, Liv Bode, Hua Huang, Chengyu Liu, Rongzhong Huang, Liang Zhang, Xiao Wang, Lujun Zhang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  5. A Roadmap for Tick-Borne Flavivirus Research in the "Omics" Era.Frontiers in cellular and infection microbiology · 2017
    Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Xia LiuDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; Department of Neurology, The Fifth People's Hospital of Shanghai, School of Medicine, Fudan University, Shanghai, 200240, China.
Libo ZhaoDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; Department of Neurology, The Third People's Hospital of Chongqing, 400014, China.
Yongtao YangDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing, 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing, 400016, China.
Liv BodeBornavirus Research Group affiliated to the Free University of Berlin, Berlin, Germany.
Hua HuangDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing, 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing, 400016, China.
Chengyu LiuChongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing, 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing, 400016, China.
Rongzhong HuangDepartment of Rehabilitative Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Liang ZhangDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing, 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing, 400016, China.
Xiao WangChongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing, 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing, 400016, China.
Lujun ZhangChongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing, 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing, 400016, China.
Siwen LiuChongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing, 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing, 400016, China.
Jingjing ZhouChongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing, 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing, 400016, China.
Xin LiJingjie PTM BioLab (Hangzhou) Co. Ltd, Hangzhou, 310018, China.
Tieming HeJingjie PTM BioLab (Hangzhou) Co. Ltd, Hangzhou, 310018, China.
Zhongyi ChengAdvanced Institute of Translational Medicine, Tongji University, Shanghai, 200092, China.
Peng XieDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing, 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing, 400016, China. Electronic address: xiepeng@cqmu.edu.cn.
The Affiliated Yongchuan Hospital of Chongqing Medical University · CNChongqing Medical University · CNDalian Medical University · CNFreie Universität Berlin · DEFudan University · CNThird People 's Hospital of Chongqing · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBorna disease virus (BDV) replicates in the nucleus and establishes persistent infections in mammalian hosts. A human BDV strain was used to address the first time, how BDV infection impacts the proteome and histone lysine acetylation (Kac) of human oligodendroglial (OL) cells, thus allowing a better understanding of infection-driven pathophysiology in vitro.

methodsProteome and histone lysine acetylation were profiled through stable isotope labeling for cell culture (SILAC)-based quantitative proteomics. The quantifiable proteome was annotated using bioinformatics. Histone acetylation changes were validated by biochemistry assays.

resultsPost BDV infection, 4383 quantifiable differential proteins were identified and functionally annotated to metabolism pathways, immune response, DNA replication, DNA repair, and transcriptional regulation. Sixteen of the thirty identified Kac sites in core histones presented altered acetylation levels post infection.

conclusionsBDV infection using a human strain impacted the whole proteome and histone lysine acetylation in OL cells.

Indexed as

AcetylationAmino Acid MotifsAmino Acid SequenceBorna DiseaseBorna disease virusFemaleHistonesHumansLysineMolecular Sequence DataOligodendrogliaProteomeProteomicsHistonesLysineProteomeBioinformatics-assisted analysisBorna disease virusHistoneHuman BDVLysine acetylationOligodendroglia cellsProteomic

Identifiers

PMID25086498
PMCPMC7112117
OpenAlexW1978190057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.