Evidence map›Paper›PMID 25086344›Full record

ReviewInternational immunopharmacology2014

Influence of farming exposure on the development of asthma and asthma-like symptoms.

Adam D Wells, Jill A Poole, Debra J Romberger

Abstract readReview
In one paragraph

Review in International immunopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Nutritional Factors in Occupational Lung Disease.Current allergy and asthma reports · 2021
    Review
  4. Article
  5. Article
  6. Review
  7. Amphiregulin modulates murine lung recovery and fibroblast function following exposure to agriculture organic dust.American journal of physiology. Lung cellular and molecular physiology · 2020
    Article
  8. Microbial interactions in the atopic march.Clinical and experimental immunology · 2020
    Review
  9. Article
  10. Review
  11. A principal factor analysis to characterize agricultural exposures among Nebraska veterans.Journal of exposure science & environmental epidemiology · 2017
    Article
  12. Article
  13. The Urban-Rural Gradient In Asthma: A Population-Based Study in Northern Europe.International journal of environmental research and public health · 2015
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adam D WellsPulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5990, USA.
Jill A PoolePulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5990, USA.
Debra J RombergerVA Nebraska-Western Iowa Health Care System, Research Service, Omaha, NE 68105, USA; Pulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5990, USA.

Funding

Role of pattern recognition receptors in organic dust-induced airway inflammationR01ES019325 · NIEHS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI POOLE, JILL A · 2010 to 2020
$3.7M
Targeting Airway Inflammation from Concentrated Animal Feeding Operation DustR01OH008539 · OH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ROMBERGER, DEBRA J · 2006 to 2014
$3.7M
NIEHS NIH HHS R01 ES019325NIOSH CDC HHS R01 OH008539
6 · The paper itself

Abstract

Based upon age and type of farming exposures, a wide range of studies demonstrate either protective or deleterious effects of the farming environment on asthma. In this review, we highlight key studies supporting the concept that farming exposure protects children from asthma and atopy based on studies performed largely in European pediatric cohorts. Various types of farming in certain regions appear to have a greater effect on asthma protection, as does the consumption of unpasteurized milk. In the United State, where concentrated animal feeding operations (CAFOs) are more common, asthma is increased in children exposed especially to swine CAFOs; whereas, rates of atopy and allergy are lower in these children. We also review studies evaluating the role of farming exposures both as a child and/or as an adult on asthma seen in adults. The importance of microbes in farming environments and the contribution of various components of the innate immune system including toll-like receptors to the underlying mechanisms of asthma related to farming exposures are also reviewed.

Indexed as

Environmental ExposureImmunity, InnateAdultAnimal FeedAnimalsAsthmaCattleChildEuropeHumansMilkSwineToll-Like ReceptorsUnited StatesToll-Like ReceptorsAsthmaAtopyFarmingInnate immunity

Identifiers

PMID25086344
PMCPMC4253718

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.