ArticleAmerican journal of obstetrics and gynecology2015
Differences in inflammatory markers between nulliparous women admitted to hospitals in preactive vs active labor.
Article in American journal of obstetrics and gynecology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Systemic inflammation is associated with malaria and preterm birth in women living with HIV on antiretrovirals and co-trimoxazole.Scientific reports · 2019Trial
- Maternal inflammation disrupts transplacental antibody transfer in pregnant individuals with and without HIV.Frontiers in immunology · 2026Article
- Effects of Dexmedetomidine or Sufentanil Plus Low-Dose Ropivacaine for Epidural Labor Analgesia on Maternal Intrapartum Temperature Changes and Delivery Outcomes.Journal of pain research · 2026Article
- Low lymphocyte-to-monocyte ratio and accelerated temperature rise in epidural-related maternal fever: a prospective cohort study.BMC anesthesiology · 2025Article
- Characterizing uterine responsiveness to oxytocin augmentation across four labor patterns in maternal obesity.Birth (Berkeley, Calif.) · 2024Article
- Fever in childbirth: a mini-review of epidural-related maternal fever.Frontiers in neuroscience · 2024Review
- Clinical chorioamnionitis at term is characterized by changes in the plasma concentration of CHCHD2/MNRR1, a mitochondrial protein.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2023Article
- Is human labor at term an inflammatory condition?†.Biology of reproduction · 2023Review
- Transcriptome changes in maternal peripheral blood during term parturition mimic perturbations preceding spontaneous preterm birth†.Biology of reproduction · 2022Article
- Decidual Inflammation Drives Chemokine-Mediated Immune Infiltration Contributing to Term Labor.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Serum markers of B-cell activation in pregnant women with atopic asthma.American journal of reproductive immunology (New York, N.Y. : 1989) · 2021Observational
- Association of lymphocyte count and incidence of maternal fever in epidural analgesia-involved labor.Annals of translational medicine · 2020Article
- Epidural Fever: Hiding in the Shadows.Turkish journal of anaesthesiology and reanimation · 2020Review
- The effects of advanced maternal age on T-cell subsets at the maternal-fetal interface prior to term labor and in the offspring: a mouse study.Clinical and experimental immunology · 2020Article
- Cell-Free Fetal DNA Increases Prior to Labor at Term and in a Subset of Preterm Births.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
- Likelihood of cesarean birth among parous women after applying leading active labor diagnostic guidelines.Midwifery · 2018Article
- Applying a physiologic partograph to Consortium on Safe Labor data to identify opportunities for safely decreasing cesarean births among nulliparous women.Birth (Berkeley, Calif.) · 2018Observational
- A Role for the Inflammasome in Spontaneous Labor at Term.American journal of reproductive immunology (New York, N.Y. : 1989) · 2018Article
- Immunophenotyping and activation status of maternal peripheral blood leukocytes during pregnancy and labour, both term and preterm.Journal of cellular and molecular medicine · 2017Article
- Likelihood of cesarean delivery after applying leading active labor diagnostic guidelines.Birth (Berkeley, Calif.) · 2017Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveTo determine whether labor-associated inflammatory markers differ between low-risk, nulliparous women in preactive vs active labor at hospital admission and over time. STUDY
designProspective comparative study of low-risk, nulliparous women with spontaneous labor onset at term (n = 118) sampled from 2 large Midwestern hospitals. Circulating concentrations of inflammatory markers were measured at admission and again 2 and 4 hours later: namely, neutrophil, and monocyte counts; and serum inflammatory cytokines (interleukin -1β, interleukin-6, tumor necrosis factor-α, interleukin-10) and chemokines (interleukin-8). Biomarker concentrations and their patterns of change over time were compared between preactive (n = 63) and active (n = 55) labor admission groups using Mann-Whitney U tests.
resultsConcentrations of interleukin-6 and interleukin-10 in the active labor admission group were significantly higher than concentrations in the preactive labor admission group at all 3 time points. Neutrophil levels were significantly higher in the active group at 2 and 4 hours after admission. The rate of increase in neutrophils and interleukin-10 between admission and 2 hours later was faster in the active group (P < .001 and P = .003, respectively).
conclusionCirculating concentrations of several inflammatory biomarkers are higher and their rate of change over time since admission is faster among low-risk, nulliparous women admitted to hospitals in active labor, as compared with those admitted in preactive labor. More research is needed to determine if progressive changes in inflammatory biomarkers might be a useful adjunct to improving the assessment of labor progression and determining the optimal timing of labor admission.
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