ArticleVirology2014
Impaired heterologous immunity in aged ferrets during sequential influenza A H1N1 infection.
Article in Virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 48 citations in OpenAlex.
- The effect of metformin treatment during primary influenza infection on heterologous challenge in young and aged mice.Frontiers in aging · 2026Article
- Elicitation of protective immune responses against influenza a viruses in elderly ferrets by adjuvanted recombinant universal influenza hemagglutinin vaccines.Immunity & ageing : I & A · 2025Article
- Modeling the CD8＋ T cell immune response to influenza infection in adult and aged mice.Journal of theoretical biology · 2024Article
- Host obesity impacts genetic variation in influenza A viral populations.Journal of virology · 2024Article
- After the virus has cleared-Can preclinical models be employed for Long COVID research?PLoS pathogens · 2022Review
- Factors Limiting the Translatability of Rodent Model-Based Intranasal Vaccine Research to Humans.AAPS PharmSciTech · 2022Review
- Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets.Scientific reports · 2021Article
- Review
- Review
- Male sex and age biases viral burden, viral shedding, and type 1 and 2 interferon responses during SARS-CoV-2 infection in ferrets.bioRxiv : the preprint server for biology · 2021Article
- Effect of aging on immunogenicity and efficacy of inactivated influenza vaccines in cotton ratsHuman vaccines & immunotherapeutics · 2021Article
- Age differences in clinical features and outcomes in patients with COVID-19, Jiangsu, China: a retrospective, multicentre cohort study.BMJ open · 2020Article
- The Power of First Impressions: Can Influenza Imprinting during Infancy Inform Vaccine Design?Vaccines · 2020Review
- Ferreting Out Influenza Virus Pathogenicity and Transmissibility: Past and Future Risk Assessments in the Ferret Model.Cold Spring Harbor perspectives in medicine · 2020Review
- Immune Imprinting in the Influenza Ferret Model.Vaccines · 2020Review
- Seasonal weight changes in laboratory ferrets.PloS one · 2020Article
- Virus-Induced T Cell-Mediated Heterologous Immunity and Vaccine Development.Frontiers in immunology · 2020Review
- A Guide for the Use of the Ferret Model for Influenza Virus Infection.The American journal of pathology · 2020Review
- Effects of cold exposure revealed by global transcriptomic analysis in ferret peripheral blood mononuclear cells.Scientific reports · 2019Article
- Age-Related Pathology Associated with H1N1 A/California/07/2009 Influenza Virus Infection.The American journal of pathology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
The major burden of influenza morbidity resides within the elderly population. The challenge managing influenza-associated illness in the elderly is the decline of immune function, where mechanisms leading to immunological senescence have not been elucidated. To better represent the immune environment, we investigated clinical morbidity and immune function during sequential homologous and heterologous H1N1 influenza infection in an aged ferret model. Our findings demonstrated experimentally that aged ferrets had significant morbidity during monosubtypic heterologous 2° challenge with significant weight loss and respiratory symptoms. Furthermore, increased clinical morbidity was associated with slower and shorter hemagglutinin antibody generation and attenuated type 1 T-cell gene responses in peripheral blood. These results revealed dampened immune activation during sequential influenza infection in aged ferrets. With the presence of an aged model, dissecting clinical morbidity, viral dynamics and immune response during influenza infection will aid the development of future prophylactics such as age specific influenza vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.