ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2014
Reproductive and hormonal risk factors for antinuclear antibodies (ANA) in a representative sample of U.S. women.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- The Impact of Autoantibodies on IVF Treatment and Outcome: A Systematic Review.International journal of molecular sciences · 2019Pooled it
- Female Infertility and Serum Auto-antibodies: a Systematic Review.Clinical reviews in allergy & immunology · 2017Pooled it
- Prevalence and association of type I IFN autoantibodies with clinical outcomes in critically ill Brazilian COVID-19 patients.Journal of human immunity · 2025Article
- Longitudinal antinuclear antibody titers in systemic lupus erythematosus and other rheumatic diseases.Frontiers in medicine · 2024Article
- Tumor-Associated and Systemic Autoimmunity in Pre-Clinical Breast Cancer among Post-Menopausal Women.Biomolecules · 2023Article
- Anti-dense fine speckled 70 (DFS70) autoantibodies: correlates and increasing prevalence in the United States.Frontiers in immunology · 2023Article
- Metal mixture exposures and multiplexed autoantibody screening in Navajo communities exposed to uranium mine wastes.Journal of translational autoimmunity · 2023Article
- Article
- Increasing Prevalence of Antinuclear Antibodies in the United States.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
- Human autoantibodies underlying infectious diseases.The Journal of experimental medicine · 2022Article
- Sex-Specific Associations Between Serum Lipids, Antinuclear Antibodies, and Statin Use in National Health and Nutrition Examination Surveys 1999-2004.Frontiers in medicine · 2022Article
- Autoantibodies neutralizing type I IFNs are present inScience immunology · 2021Article
- Antinuclear Antibody Profiling in Patients of a Tertiary Care Centre in Central India.Indian journal of clinical biochemistry : IJCB · 2021Article
- Article
- Increasing Prevalence of Antinuclear Antibodies in the United States.Arthritis & rheumatology (Hoboken, N.J.) · 2020Article
- Evaluation of the Ovarian Reserve in Adolescents with Hashimoto’s Thyroiditis Using Serum Anti-Müllerian Hormone LevelsJournal of clinical research in pediatric endocrinology · 2018Article
- Prescription medication use and antinuclear antibodies in the United States, 1999-2004.Journal of autoimmunity · 2018Article
- Recent Approaches To Optimize Laboratory Assessment of Antinuclear Antibodies.Clinical and vaccine immunology : CVI · 2017Review
- Antinuclear antibodies and mortality in the National Health and Nutrition Examination Survey (1999-2004).PloS one · 2017Article
- Association between Vitamin D Deficiency and Antinuclear Antibodies in Middle-Aged and Older U.S. Adults.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAutoantibodies are of growing interest in cancer research as potential biomarkers; yet, the determinants of autoimmunity are not well understood. Antinuclear antibodies (ANA) are common in the general population and are more prevalent in women and older adults. Here, we examined the relationship of ANA with reproductive and hormonal factors in a representative sample of U.S. women.
methodsWe analyzed data on reproductive history and exogenous hormone use in relation to serum ANA in 2,037 females ages 12 years and older from the National Health and Nutrition Examination Survey (NHANES; 1999-2004). Estimated ANA prevalences were adjusted for sampling weights. Prevalence ORs (POR) and 95% confidence intervals (CI) were adjusted for age, race, and poverty-income ratio, and models were stratified by menopause status.
resultsIn premenopausal women ages 20 years and older, ANA prevalence was associated with parity (P < 0.001; parous vs. nulliparous POR = 2.0; 95% CI, 1.2-3.4), but in parous women, ANA did not vary by number of births, age at first birth, years since last birth, or breastfeeding. In postmenopausal women, ANA prevalence was associated with an older age at menarche (P = 0.019; age 16-20 vs. 10-12 years POR = 3.0; 95% CI, 1.6-5.9), but not with parity. Oral contraceptives and estrogen therapy were not associated with a higher ANA prevalence.
conclusionsChildbearing (having had one or more births) may explain age-associated elevations in ANA prevalence seen in premenopausal women. IMPACT: These findings highlight the importance of considering reproductive history in studies of autoimmunity and cancer in women.
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