ArticleThe Journal of rheumatology2014
Alpha-chlorofatty Acid and coronary artery or aorta calcium scores in women with systemic lupus erythematosus. A pilot study.
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Article in The Journal of rheumatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Plasmalogen Loss in Sepsis and SARS-CoV-2 Infection.Frontiers in cell and developmental biology · 2022Article
- 2-Chlorofatty acids are biomarkers of sepsis mortality and mediators of barrier dysfunction in rats.Journal of lipid research · 2020Article
- The chlorinated lipidome originating from myeloperoxidase-derived HOCl targeting plasmalogens: Metabolism, clearance, and biological properties.Archives of biochemistry and biophysics · 2018Review
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Authors and funding
8 authors at 5 institutions in 2 countries.
Mary A MahieuFrom the Department of Medicine, Division of Rheumatology, and Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Departments of Pediatrics and Center for Outcomes Research and of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University, Saint Louis, Missouri; Department of Medicine, Section of Cardiology, University of Illinois at Chicago College of Medicine, Chicago, Illinois; and Department of Medicine, Section of Cardiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.M.A. Mahieu, MD, Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine; C.P. Guild, MPH, Department of Pediatrics and Center for Outcomes Research, Saint Louis University School of Medicine; C.J. Albert, BA, Department of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University School of Medicine; G.T. Kondos, MD, Department of Medicine, Section of Cardiology, University of Illinois Chicago College of Medicine; J.J. Carr, MD, Department of Radiology, Northwestern University Feinberg School of Medicine; D. Edmundowicz, MD, Department of Medicine, Section of Cardiology, Temple University School of Medicine; D.A. Ford, PhD, Department of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University School of Medicine; R. Ramsey-Goldman, MD, DrPH, Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine. mary-mahieu@northwestern.edu.
Camelia P GuildFrom the Department of Medicine, Division of Rheumatology, and Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Departments of Pediatrics and Center for Outcomes Research and of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University, Saint Louis, Missouri; Department of Medicine, Section of Cardiology, University of Illinois at Chicago College of Medicine, Chicago, Illinois; and Department of Medicine, Section of Cardiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.M.A. Mahieu, MD, Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine; C.P. Guild, MPH, Department of Pediatrics and Center for Outcomes Research, Saint Louis University School of Medicine; C.J. Albert, BA, Department of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University School of Medicine; G.T. Kondos, MD, Department of Medicine, Section of Cardiology, University of Illinois Chicago College of Medicine; J.J. Carr, MD, Department of Radiology, Northwestern University Feinberg School of Medicine; D. Edmundowicz, MD, Department of Medicine, Section of Cardiology, Temple University School of Medicine; D.A. Ford, PhD, Department of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University School of Medicine; R. Ramsey-Goldman, MD, DrPH, Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine.
Carolyn J AlbertFrom the Department of Medicine, Division of Rheumatology, and Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Departments of Pediatrics and Center for Outcomes Research and of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University, Saint Louis, Missouri; Department of Medicine, Section of Cardiology, University of Illinois at Chicago College of Medicine, Chicago, Illinois; and Department of Medicine, Section of Cardiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.M.A. Mahieu, MD, Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine; C.P. Guild, MPH, Department of Pediatrics and Center for Outcomes Research, Saint Louis University School of Medicine; C.J. Albert, BA, Department of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University School of Medicine; G.T. Kondos, MD, Department of Medicine, Section of Cardiology, University of Illinois Chicago College of Medicine; J.J. Carr, MD, Department of Radiology, Northwestern University Feinberg School of Medicine; D. Edmundowicz, MD, Department of Medicine, Section of Cardiology, Temple University School of Medicine; D.A. Ford, PhD, Department of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University School of Medicine; R. Ramsey-Goldman, MD, DrPH, Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine.
George T KondosFrom the Department of Medicine, Division of Rheumatology, and Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Departments of Pediatrics and Center for Outcomes Research and of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University, Saint Louis, Missouri; Department of Medicine, Section of Cardiology, University of Illinois at Chicago College of Medicine, Chicago, Illinois; and Department of Medicine, Section of Cardiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.M.A. Mahieu, MD, Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine; C.P. Guild, MPH, Department of Pediatrics and Center for Outcomes Research, Saint Louis University School of Medicine; C.J. Albert, BA, Department of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University School of Medicine; G.T. Kondos, MD, Department of Medicine, Section of Cardiology, University of Illinois Chicago College of Medicine; J.J. Carr, MD, Department of Radiology, Northwestern University Feinberg School of Medicine; D. Edmundowicz, MD, Department of Medicine, Section of Cardiology, Temple University School of Medicine; D.A. Ford, PhD, Department of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University School of Medicine; R. Ramsey-Goldman, MD, DrPH, Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine.
James J CarrFrom the Department of Medicine, Division of Rheumatology, and Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Departments of Pediatrics and Center for Outcomes Research and of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University, Saint Louis, Missouri; Department of Medicine, Section of Cardiology, University of Illinois at Chicago College of Medicine, Chicago, Illinois; and Department of Medicine, Section of Cardiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.M.A. Mahieu, MD, Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine; C.P. Guild, MPH, Department of Pediatrics and Center for Outcomes Research, Saint Louis University School of Medicine; C.J. Albert, BA, Department of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University School of Medicine; G.T. Kondos, MD, Department of Medicine, Section of Cardiology, University of Illinois Chicago College of Medicine; J.J. Carr, MD, Department of Radiology, Northwestern University Feinberg School of Medicine; D. Edmundowicz, MD, Department of Medicine, Section of Cardiology, Temple University School of Medicine; D.A. Ford, PhD, Department of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University School of Medicine; R. Ramsey-Goldman, MD, DrPH, Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine.
Daniel EdmundowiczFrom the Department of Medicine, Division of Rheumatology, and Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Departments of Pediatrics and Center for Outcomes Research and of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University, Saint Louis, Missouri; Department of Medicine, Section of Cardiology, University of Illinois at Chicago College of Medicine, Chicago, Illinois; and Department of Medicine, Section of Cardiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.M.A. Mahieu, MD, Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine; C.P. Guild, MPH, Department of Pediatrics and Center for Outcomes Research, Saint Louis University School of Medicine; C.J. Albert, BA, Department of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University School of Medicine; G.T. Kondos, MD, Department of Medicine, Section of Cardiology, University of Illinois Chicago College of Medicine; J.J. Carr, MD, Department of Radiology, Northwestern University Feinberg School of Medicine; D. Edmundowicz, MD, Department of Medicine, Section of Cardiology, Temple University School of Medicine; D.A. Ford, PhD, Department of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University School of Medicine; R. Ramsey-Goldman, MD, DrPH, Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine.
David A FordFrom the Department of Medicine, Division of Rheumatology, and Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Departments of Pediatrics and Center for Outcomes Research and of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University, Saint Louis, Missouri; Department of Medicine, Section of Cardiology, University of Illinois at Chicago College of Medicine, Chicago, Illinois; and Department of Medicine, Section of Cardiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.M.A. Mahieu, MD, Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine; C.P. Guild, MPH, Department of Pediatrics and Center for Outcomes Research, Saint Louis University School of Medicine; C.J. Albert, BA, Department of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University School of Medicine; G.T. Kondos, MD, Department of Medicine, Section of Cardiology, University of Illinois Chicago College of Medicine; J.J. Carr, MD, Department of Radiology, Northwestern University Feinberg School of Medicine; D. Edmundowicz, MD, Department of Medicine, Section of Cardiology, Temple University School of Medicine; D.A. Ford, PhD, Department of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University School of Medicine; R. Ramsey-Goldman, MD, DrPH, Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine.
Rosalind Ramsey-GoldmanFrom the Department of Medicine, Division of Rheumatology, and Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Departments of Pediatrics and Center for Outcomes Research and of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University, Saint Louis, Missouri; Department of Medicine, Section of Cardiology, University of Illinois at Chicago College of Medicine, Chicago, Illinois; and Department of Medicine, Section of Cardiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.M.A. Mahieu, MD, Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine; C.P. Guild, MPH, Department of Pediatrics and Center for Outcomes Research, Saint Louis University School of Medicine; C.J. Albert, BA, Department of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University School of Medicine; G.T. Kondos, MD, Department of Medicine, Section of Cardiology, University of Illinois Chicago College of Medicine; J.J. Carr, MD, Department of Radiology, Northwestern University Feinberg School of Medicine; D. Edmundowicz, MD, Department of Medicine, Section of Cardiology, Temple University School of Medicine; D.A. Ford, PhD, Department of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University School of Medicine; R. Ramsey-Goldman, MD, DrPH, Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine.
University of Illinois Chicago · USSaint Louis University · USCenter for Rheumatology · USTemple College · USTemple University · US
Funding
MULTIDISCIPLINARY CLINICAL AND TRANSLATIONAL SCIENCE (MCTS) PROGRAM (UL1)UL1RR025741 · NCRR · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GREENLAND, PHILIP · 2008 to 2011
$24.7MPlasmalogen-derived bioactive lipids in atherosclerosisR01HL074214 · NHLBI · SAINT LOUIS UNIVERSITY · PI FORD, DAVID A. · 2004 to 2014
$2.8MSUPERANTIGEN INTERACTIONS WITH MHC CLASS II ANTIGENSP60AR030692 · NIAMS · NORTHWESTERN UNIVERSITY · PI POPE, RICHARD M. · 1986 to 2001
$2.1MSerum chlorinated lipids as predictors of cardiovascular risk in lupusR21HL098907 · NHLBI · SAINT LOUIS UNIVERSITY · PI FORD, DAVID A. · 2010 to 2011
$419kTSQ QUANTUM ESI-MS SURVEYOR BUNDLE: RENAL, HEART, RETINAL, &LUNG DISEASESS10RR019232 · NCRR · SAINT LOUIS UNIVERSITY · PI FORD, DAVID A. · 2004 to 2004
$339kNCRR NIH HHS RR019232NCRR NIH HHS S10 RR019232NCRR NIH HHS UL1 RR025741NCRR NIH HHS UL1RR025741NHLBI NIH HHS HL074214NHLBI NIH HHS HL098907NHLBI NIH HHS R01 HL074214NHLBI NIH HHS R21 HL098907NIAMS NIH HHS P60 AR030692NIAMS NIH HHS P60AR30692
Abstract
objectiveAlpha-chlorofatty acid (α-ClFA) is one product of myeloperoxidase activity in vivo during atherogenesis and may be a biomarker for cardiovascular disease (CVD). We investigated if serum α-ClFA is associated with subclinical CVD as measured by coronary artery and aorta calcium scores (CAC and AC, respectively) in women with and without systemic lupus erythematosus (SLE).
methodsThis pilot project analyzed baseline data from 173 women with SLE and 186 women without SLE participating in a 5-year longitudinal investigation of the Study of Lupus Vascular and Bone Long-term Endpoints (SOLVABLE). Data collection included demographic information, CVD and SLE risk factors, and laboratory assessments. Alpha-ClFA was measured in stored serum by liquid chromatography-mass spectrometry. CAC and AC were measured by computed tomography. Outcome measures were CAC and AC present (CAC > 0 or AC > 0) versus absent (CAC = 0 or AC = 0). Associations between risk factors and CAC or AC were tested with descriptive statistics and multivariate analyses.
resultsWomen with SLE had higher α-ClFA levels than women without SLE (42.0 fmol/25 µl ± 37.3 vs 34.5 fmol/25 µl ± 21.9; p = 0.020). In analyses including individual CVD risk factors, having SLE was independently associated with the presence of CAC (OR 3.42, 95% CI 1.72 to 6.78) but not AC. Alpha-ClFA was not associated with the presence of CAC or AC in patients with SLE.
conclusionSLE, but not serum α-ClFA, was associated with the presence of CAC in this pilot project.
Indexed as
AdultAgedAortaAortographyBiomarkersCalciumCardiovascular DiseasesCoronary VesselsFatty AcidsFemaleHumansLupus Erythematosus, SystemicMiddle AgedPilot ProjectsRisk FactorsBiomarkersCalciumFatty AcidsAORTA CALCIUMCARDIOVASCULAR DISEASECORONARY ARTERY CALCIUMSYSTEMIC LUPUS ERYTHEMATOSUS
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