ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2015
Age and gender modulate the neural circuitry supporting facial emotion processing in adults with major depressive disorder.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 5 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Neural correlates of peripartum depression: a systematic review, meta-analysis and comparison to major depressive disorder.Molecular psychiatry · 2025Pooled it
- Brain-based Sex Differences in Depression: A Systematic Review of Neuroimaging Studies.Brain imaging and behavior · 2023Pooled it
- The conscious processing of emotion in depression disorder: a meta-analysis of neuroimaging studies.Frontiers in psychiatry · 2023Pooled it
- Structural and functional neuroimaging of late-life depression: a coordinate-based meta-analysis.Brain imaging and behavior · 2022Pooled it
- Abnormal neural activities in adults and youths with major depressive disorder during emotional processing: a meta-analysis.Brain imaging and behavior · 2021Pooled it
- Sex differences in placebo and antidepressant response to intranasal esketamine for treatment-resistant depression.Molecular psychiatry · 2026Article
- Sex differences in activations to the sight of faces, scenes, body parts and tools in visual and non-visual cortical regions leading to the human hippocampus.Biology of sex differences · 2026Article
- Mindfulness meditation reduces symptoms and modulates neural circuitry in comorbid internet gaming disorder and depression.PNAS nexus · 2025Article
- Altered brain structure age gap estimation in major depressive disorder patients with and without anhedonia: a machine learning-based study.Translational psychiatry · 2025Article
- Neural Functioning in Late-Life Depression: An Activation Likelihood Estimation Meta-Analysis.Geriatrics (Basel, Switzerland) · 2024Review
- Sex-specific resting state brain network dynamics in patients with major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- The need to change: Is there a critical role of midlife adaptation in mental health later in life?eLife · 2023Review
- FMRI study of implicit emotional face processing in patients with MDD with melancholic subtype.Frontiers in human neuroscience · 2023Article
- Human emotion processing accuracy, negative biases, and fMRI activation are associated with childhood trauma.Frontiers in psychiatry · 2023Article
- Impact of prenatal maternal cytokine exposure on sex differences in brain circuitry regulating stress in offspring 45 years later.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Disrupted Regional Homogeneity in Melancholic and Non-melancholic Major Depressive Disorder at Rest.Frontiers in psychiatry · 2021Article
- Emotion processing in depression and anxiety disorders in older adults: systematic review.BJPsych open · 2020Article
- Sex differences in major depression and comorbidity of cardiometabolic disorders: impact of prenatal stress and immune exposures.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Considering sex differences clarifies the effects of depression on facial emotion processing during fMRI.Journal of affective disorders · 2018Article
- Faces on Her and His Mind: Female and Likable.PloS one · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesEmotion processing, supported by frontolimbic circuitry known to be sensitive to the effects of aging, is a relatively understudied cognitive-emotional domain in geriatric depression. Some evidence suggests that the neurophysiological disruption observed in emotion processing among adults with major depressive disorder (MDD) may be modulated by both gender and age. Therefore, the present study investigated the effects of gender and age on the neural circuitry supporting emotion processing in MDD.
designCross-sectional comparison of fMRI signal during performance of an emotion processing task.
settingOutpatient university setting.
participantsOne hundred adults recruited by MDD status, gender, and age. MEASUREMENTS: Participants underwent fMRI while completing the Facial Emotion Perception Test. They viewed photographs of faces and categorized the emotion perceived. Contrast for fMRI was of face perception minus animal identification blocks.
resultsEffects of depression were observed in precuneus and effects of age in a number of frontolimbic regions. Three-way interactions were present between MDD status, gender, and age in regions pertinent to emotion processing, including frontal, limbic, and basal ganglia. Young women with MDD and older men with MDD exhibited hyperactivation in these regions compared with their respective same-gender healthy comparison (HC) counterparts. In contrast, older women and younger men with MDD exhibited hypoactivation compared to their respective same-gender HC counterparts.
conclusionsThis the first study to report gender- and age-specific differences in emotion processing circuitry in MDD. Gender-differential mechanisms may underlie cognitive-emotional disruption in older adults with MDD. The present findings have implications for improved probes into the heterogeneity of the MDD syndrome.
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