Observational studyInternational journal of cardiology2014
Association of systolic blood pressure levels with cardiovascular events and all-cause mortality among older adults taking antihypertensive medication.
Observational study in International journal of cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Eplerenone for hypertension.The Cochrane database of systematic reviews · 2017Pooled it
- Solid reasons to equitably screen.Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2025Article
- Association of socioeconomic status with prognosis in hypertensive patients over age 65: a cohort study in the community setting.BMJ open · 2024Article
- Optimal Systolic Blood Pressure for the Prevention of All-Cause and Cardiovascular Disease Mortality in Older Adults With Hypertension: Nationwide Population-Based Cohort Study.JMIR public health and surveillance · 2024Article
- Effect of 10-year cumulative blood pressure exposure on atherosclerotic cardiovascular disease of different age groups: kailuan cohort study.Frontiers in cardiovascular medicine · 2024Article
- Impact of hypertension diagnosis on morbidity and mortality: a retrospective cohort study in primary care.BMC primary care · 2023Article
- Article
- Epidemiology of hypertensive heart disease in Poland: findings from the Global Burden of Disease Study 2016.Archives of medical science : AMS · 2021Article
- Association of optimal blood pressure with mortality in patients taking antihypertensive medications.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Managing Hypertension in the elderly: What's new?American journal of preventive cardiology · 2020Review
- Ambulatory blood-pressure monitoring, antihypertensive therapy and the risk of fall injuries in elderly hypertensive patients.Journal of geriatric cardiology : JGC · 2018Article
- Managing Hypertension in Patients Aged 75 Years and Older.Current hypertension reports · 2017Review
- Design and implementation of a combined observational and interventional study: Trends of prevalence, awareness, treatment and control hypertension and the effect of expanded chronic care model on control, treatment and self-care.ARYA atherosclerosis · 2017Article
- Blood Pressure, Antihypertensive Polypharmacy, Frailty, and Risk for Serious Fall Injuries Among Older Treated Adults With Hypertension.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Managing Hypertension in the Elderly: What is Different, What is the Same?Current hypertension reports · 2017Review
- Measures of Kidney Disease and the Risk of Venous Thromboembolism in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017Article
- Risk Factor of Cardiovascular Disease Among Older Individuals.Journal of atherosclerosis and thrombosis · 2017Article
- Predictive Value of Cumulative Blood Pressure for All-Cause Mortality and Cardiovascular Events.Scientific reports · 2017Article
- What should the target blood pressure goals be?Archives of medical science : AMS · 2016Article
- What should the blood pressure treatment goal be in adults with hypertension in 2016?Annals of translational medicine · 2016Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
introductionThe aim of the study was to identify the association of systolic blood pressure (SBP) levels with cardiovascular events, all-cause mortality, and falls among elderly persons taking antihypertensive medication.
methodsUS adults ≥ 45 years of age taking antihypertensive medication enrolled in the REGARDS study were categorized into 3 age groups: 55-64, 65-74 and ≥ 75 years old and baseline on-treatment SBP levels. Our primary analyses focused on incident cardiovascular disease (CVD) (n=9787) and all-cause mortality (n=13,948).
resultsDuring follow-up, 530 (5.4%) participants had CVD events and 2095 (15%) participants died. After multivariable adjustment among participants ≥ 75, the incidence of CVD per 1000 person-years (95% confidence interval) was 16.9 (11.1-25.7), 13.4 (9.2-19.7), 11.6 (7.6-17.7), 17.8 (11.2-27.5) and 36.7 (26.6-50.8) at SBP levels of <120, 120-129, 130-139, 140-149, and ≥ 150 mmHg, respectively. For the same SBP categories, the adjusted CVD incidence rates were 9.3 (7.2-12.0), 10.0 (8.1-12.3), 9.4 (7.5-11.8), 14.0 (11.0-17.8), and 16.4 (12.5-21.4), respectively, among participants 55-64 years, and 16.5 (13.6-21.5), 17.4 (14.8-20.6), 19.2 (16.4-22.5), 22.3 (18.6-26.9), and 27.6 (22.7-33.4), respectively, for participants 65-74 years. Among participants aged 55-64 and 65-74 years, a linear association was present between higher SBP categories and all-cause mortality risk (each p-trend<0.001). In contrast, for participants ≥ 75 years no association was present between SBP and all-cause mortality (p-trend=0.319). No association was observed between SBP and falls among participants in all age groups.
conclusionsAmong adults aged ≥ 55 taking antihypertensive medication, SBP between 120 and 139 mmHg was significantly associated with a reduced risk for cardiovascular and all-cause mortality outcomes.
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Registered trials
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