Evidence map›Paper›PMID 25085354›Full record

ArticleHaematologica2014

Favorable impact of natural killer cell reconstitution on chronic graft-versus-host disease and cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation.

Vissal David Kheav, Marc Busson, Catherine Scieux, Régis Peffault de Latour, Guitta Maki, Philippe Haas, Marie-Christine Mazeron, Maryvonnick Carmagnat, Emeline Masson, Aliénor Xhaard and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

Vissal David KheavAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie et Histocompatibilité, Paris Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie Paris; INSERM UMRS-1160, Paris;
Marc BussonUniversité Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie Paris; INSERM UMRS-1160, Paris;
Catherine ScieuxUniversité Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie Paris; AP-HP, Hôpital Saint-Louis, Laboratoire de Microbiologie, Paris, France.
Régis Peffault de LatourUniversité Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie Paris; AP-HP, Hôpital Saint-Louis, Service d'Hématologie-Greffe de Moelle, Paris;
Guitta MakiAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie et Histocompatibilité, Paris.
Philippe HaasAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie et Histocompatibilité, Paris Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie Paris; INSERM UMRS-1160, Paris;
Marie-Christine MazeronUniversité Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie Paris; AP-HP, Hôpital Saint-Louis, Laboratoire de Microbiologie, Paris, France.
Maryvonnick CarmagnatAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie et Histocompatibilité, Paris.
Emeline MassonAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie et Histocompatibilité, Paris.
Aliénor XhaardAP-HP, Hôpital Saint-Louis, Service d'Hématologie-Greffe de Moelle, Paris;
Marie RobinAP-HP, Hôpital Saint-Louis, Service d'Hématologie-Greffe de Moelle, Paris;
Patricia RibaudAP-HP, Hôpital Saint-Louis, Service d'Hématologie-Greffe de Moelle, Paris;
Nicolas DulphyAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie et Histocompatibilité, Paris Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie Paris; INSERM UMRS-1160, Paris;
Pascale LoiseauAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie et Histocompatibilité, Paris INSERM UMRS-1160, Paris;
Dominique CharronAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie et Histocompatibilité, Paris Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie Paris;
Gérard SociéUniversité Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie Paris; INSERM UMRS-1160, Paris; AP-HP, Hôpital Saint-Louis, Service d'Hématologie-Greffe de Moelle, Paris;
Antoine ToubertAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie et Histocompatibilité, Paris Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie Paris; INSERM UMRS-1160, Paris; helene.moins@univ-paris-diderot.fr antoine.toubert@univ-paris-diderot.fr.
Hélène Moins-TeisserencAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie et Histocompatibilité, Paris Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie Paris; INSERM UMRS-1160, Paris; helene.moins@univ-paris-diderot.fr antoine.toubert@univ-paris-diderot.fr.
Assistance Publique – Hôpitaux de Paris · FRHôpital Saint-Louis · FRSorbonne Paris Cité · FRUniversité Paris Cité · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural killer cells are the first lymphocyte subset to reconstitute, and play a major role in early immunity after allogeneic hematopoietic stem cell transplantation. Cells expressing the activating receptor NKG2C seem crucial in the resolution of cytomegalovirus episodes, even in the absence of T cells. We prospectively investigated natural killer-cell reconstitution in a cohort of 439 adult recipients who underwent non-T-cell-depleted allogeneic hematopoietic stem cell transplantation between 2005 and 2012. Freshly collected blood samples were analyzed 3, 6, 12 and 24 months after transplantation. Data were studied with respect to conditioning regimen, source of stem cells, underlying disease, occurrence of graft-versus-host disease, and profiles of cytomegalovirus reactivation. In multivariate analysis we found that the absolute numbers of CD56(bright) natural killer cells at month 3 were significantly higher after myeloablative conditioning than after reduced intensity conditioning. Acute graft-versus-host disease impaired reconstitution of total and CD56(dim) natural killer cells at month 3. In contrast, high natural killer cell count at month 3 was associated with a lower incidence of chronic graft-versus-host disease, independently of a previous episode of acute graft-versus-host disease and stem cell source. NKG2C(+)CD56(dim) and total natural killer cell counts at month 3 were lower in patients with reactivation of cytomegalovirus between month 0 and month 3, but expanded greatly afterwards. These cells were also less numerous in patients who experienced later cytomegalovirus reactivation between month 3 and month 6. Our results advocate a direct role of NKG2C-expressing natural killer cells in the early control of cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation.

Indexed as

AdolescentAdultChronic DiseaseCytomegalovirusCytomegalovirus InfectionsFemaleFlow CytometryFollow-Up StudiesGraft vs Host DiseaseHematologic NeoplasmsHematopoietic Stem Cell TransplantationHumansKiller Cells, NaturalLymphocyte SubsetsMaleNeoplasm Staging

Identifiers

PMID25085354
PMCPMC4258747
OpenAlexW2162289477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.