ReviewThe Surgical clinics of North America2014
Biology and principles of scar management and burn reconstruction.
Review in The Surgical clinics of North America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04236167 (Evaluating the Efficacy of an Ablative Fractional Carbon Dioxide Laser on Pathologic Symptoms in Pediatric Hypertrophic Scars), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating the Efficacy of an Ablative Fractional Carbon Dioxide Laser on Pathologic Symptoms in Pediatric Hypertrophic Scars: a Prospective Split-scar Controlled Trial
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- A systematic review evaluating the influence of incisional Negative Pressure Wound Therapy on scarring.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2021Pooled it
- Heterotopic Ossification: Molecular Drivers, Subtype-Specific Mechanisms, and Translational Therapeutic Advances.Biomolecules · 2026Review
- Circadian Gene NPAS2 Relieves Hypertrophic Scar Formation via CDC25A-Mediated Fibroblasts Activity.Journal of cellular and molecular medicine · 2025Article
- Fractional CO2 Laser for Burn Scars: A Comparison of Patient-Reported Outcomes Between Those With and Without Laser Treatment.Journal of burn care & research : official publication of the American Burn Association · 2024Article
- Fractional CO₂ Laser Therapy for Effective Treatment of Facial Traumatic Hypertrophic Scar: A Case Report.The American journal of case reports · 2024Article
- Acne-induced pathological scars: pathophysiology and current treatments.Burns & trauma · 2024Review
- Fibrosis in burns: an overview of mechanisms and therapies.American journal of physiology. Cell physiology · 2023Review
- Topical vanadate improves tensile strength and alters collagen organisation of excisional wounds in a mouse model.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2023Article
- The Efficacy of Intense Pulsed Light in the Treatment of Keloids and Hypertrophic Scars.Journal of lasers in medical sciences · 2023Article
- Comparative Transcriptome Analysis of Superficial and Deep Partial-Thickness Burn Wounds in Yorkshire vs Red Duroc Pigs.Journal of burn care & research : official publication of the American Burn Association · 2022Article
- Review
- Pharmaceutical Prophylaxis of Scarring with Emphasis on Burns: A Review of Preclinical and Clinical Studies.Advances in wound care · 2022Review
- Needling, lasers, and Meso-Botox for hypertrophic and keloidal scars: A comprehensive review study on promising procedural treatments.Journal of family medicine and primary care · 2022Review
- [Clinical application and related research advances of negative pressure wound therapy in wound treatment].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Review
- [Regulatory effects of bio-intensity electric field on transformation of human skin fibroblasts].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- Article
- Paediatric chemical burns: a clinical review.European journal of pediatrics · 2021Review
- BioflavonoidEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Evolution of ischemia and neovascularization in a murine model of full thickness human wound healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2020Article
- Current Approaches Targeting the Wound Healing Phases to Attenuate Fibrosis and Scarring.International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Hypertrophic scarring is extremely common and is the source of most morbidity related to burns. The biology of hypertrophic healing is complex and poorly understood. Multiple host and injury factors contribute, but protracted healing of partial thickness injury is a common theme. Hypertrophic scarring and heterotopic ossification may share some basic causes involving marrow-derived cells. Several traditional clinical interventions exist to modify hypertrophic scar. All have limited efficacy. Laser interventions for scar modification show promise, but as yet do not provide a definitive solution. Their efficacy is only seen when used as part of a multimodality scar management program.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.