Evidence map›Paper›PMID 25084689›Full record

ArticleClinical imaging

Isolated intracerebral light chain deposition disease: novel imaging and pathologic findings.

John-Paul J Yu, David M Wilson, Edward F Chang, Jennifer Cotter, Arie Perry, Anuj Mahindra, Christine M Glastonbury

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

John-Paul J YuUniversity of California, San Francisco, Department of Radiology and Biomedical Imaging, 505 Parnassus Ave., M-391, San Francisco, CA 94143-0628. Electronic address: jp.yu@ucsf.edu.
David M WilsonUniversity of California, San Francisco, Department of Radiology and Biomedical Imaging, 505 Parnassus Ave., M-391, San Francisco, CA 94143-0628.
Edward F ChangUniversity of California, San Francisco, Departments of Neurological Surgery and Physiology and Center for Integrative Neuroscience, 505 Parnassus Ave., M-779, San Francisco, CA 94143-0112.
Jennifer CotterUniversity of California, San Francisco, Department of Pathology, 505 Parnassus Ave., M-551, San Francisco, CA, 94143-0102.
Arie PerryUniversity of California, San Francisco, Department of Pathology, 505 Parnassus Ave., M-551, San Francisco, CA, 94143-0102.
Anuj MahindraUniversity of California, San Francisco, Department of Medicine, 505 Parnassus Ave., Box 0324, San Francisco, CA, 94143-0324.
Christine M GlastonburyUniversity of California, San Francisco, Department of Radiology and Biomedical Imaging, 505 Parnassus Ave., M-391, San Francisco, CA 94143-0628.
University of California, San Francisco · US

Funding

Biomedical Imaging for Clinician ScientistsT32EB001631 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI THOMAS M LINK · 2005 to 2026
$5.6M
Ascorbate-based biomarkers for predicting radiation response in prostate cancerR01CA166766 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WILSON, DAVID M · 2012 to 2016
$2.4M
NCI NIH HHS R01 CA166766NIBIB NIH HHS T32 EB001631
6 · The paper itself

Abstract

Light chain deposition disease (LCDD) is a rare clinicopathologic entity first described in 1976 and is characterized by a monoclonal gammopathy resulting in nonamyloid immunoglobulin light chain tissue deposition. Only four cases of intracerebral LCDD have been previously reported, all in the setting of a known plasma cell dyscrasia or in the presence of local mature plasma cells. We present the first case of intracranial LCDD in the absence of a known plasma cell dyscrasia or local mature plasma cells.

Indexed as

Immunoglobulin Light ChainsAdultBrainBrain DiseasesDiagnosis, DifferentialFemaleHumansMagnetic Resonance ImagingParaproteinemiasImmunoglobulin Light ChainsAmyloidomaLight chain deposition diseaseMonoclonal immunoglobulin deposition diseaseMRI

Identifiers

PMID25084689
PMCPMC4854295
OpenAlexW1973740491

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.