ArticleAmerican journal of preventive medicine2014
Regular fish consumption and age-related brain gray matter loss.
Article in American journal of preventive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Fish consumption and brain structure: a comprehensive systematic review of observational studies.Aging clinical and experimental research · 2026Pooled it
- Dietary diversity and cognitive performance in older adults: a systematic review.BMC neurology · 2025Pooled it
- Trial
- Fish Oil Supplementation Increases Event-Related Posterior Cingulate Activation in Older Adults with Subjective Memory Impairment.The journal of nutrition, health & aging · 2016Trial
- Higher Total Omega-3 PUFA Levels and a Lower Omega-6:Omega-3 Ratio Are Associated with Lower Temporal Lobe Volume in Alzheimer's Disease.Molecular neurobiology · 2026Article
- Nourishing the Brain or the Mood? Dietary Omega-3s for Psychological, but Not Cognitive Health.Nutrients · 2025Article
- Longitudinal study of seafood and fish oil supplement intake and risk of persistent tinnitus.The American journal of clinical nutrition · 2024Article
- Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults.Nutrients · 2024Article
- Article
- Exploring sex differences: insights into gene expression, neuroanatomy, neurochemistry, cognition, and pathology.Frontiers in neuroscience · 2024Review
- Association between dietary niacin intake and cognitive function in the elderly: Evidence from NHANES 2011-2014.Food science & nutrition · 2023Article
- The role of diet in multiple sclerosis onset and course: results from a nationwide retrospective birth-year cohort.Annals of clinical and translational neurology · 2023Article
- Handgrip Strength Is Related to Hippocampal and Lobar Brain Volumes in a Cohort of Cognitively Impaired Older Adults with Confirmed Amyloid Burden.Journal of Alzheimer's disease : JAD · 2023Article
- Associations of dairy, meat, and fish intakes with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD).European journal of nutrition · 2022Article
- Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study.Frontiers in aging neuroscience · 2022Article
- Associations Between Dietary Patterns and Neuroimaging Markers: A Systematic Review.Frontiers in nutrition · 2022Review
- Proximate Composition and Nutritional Attributes of Ready-to-Cook Catfish Products.Foods (Basel, Switzerland) · 2021Article
- Can Natural Products Exert Neuroprotection without Crossing the Blood-Brain Barrier?International journal of molecular sciences · 2021Review
- Case Study: A Precision Medicine Approach to Multifactorial Dementia and Alzheimer's Disease.Journal of Alzheimer's disease & Parkinsonism · 2021Article
- Perceived Risk of Fish Consumption in a Low Fish Consumption Country.Foods (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundBrain health may be affected by modifiable lifestyle factors; consuming fish and antioxidative omega-3 fatty acids may reduce brain structural abnormality risk. PURPOSE: To determine whether dietary fish consumption is related to brain structural integrity among cognitively normal elders.
methodsData were analyzed from 260 cognitively normal individuals from the Cardiovascular Health Study with information on fish consumption from the National Cancer Institute Food Frequency Questionnaire and brain magnetic resonance imaging (MRI). The relationship between fish consumption data collected in 1989-1990 and brain structural MRI obtained in 1998-1999 was assessed using voxel-based morphometry in multiple regression analyses in 2012. Covariates were age, gender, race, education, white matter lesions, MRI-identified infarcts, waist-hip ratio, and physical activity as assessed by the number of city blocks walked in 1 week. Volumetric changes were further modeled with omega-3 fatty acid estimates to better understand the mechanistic link between fish consumption, brain health, and Alzheimer disease.
resultsWeekly consumption of baked or broiled fish was positively associated with gray matter volumes in the hippocampus, precuneus, posterior cingulate, and orbital frontal cortex even after adjusting for covariates. These results did not change when including omega-3 fatty acid estimates in the analysis.
conclusionsDietary consumption of baked or broiled fish is related to larger gray matter volumes independent of omega-3 fatty acid content. These findings suggest that a confluence of lifestyle factors influence brain health, adding to the growing body of evidence that prevention strategies for late-life brain health need to begin decades earlier.
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