ArticlePloS one2014
Host adaptation of Chlamydia pecorum towards low virulence evident in co-evolution of the ompA, incA, and ORF663 Loci.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- The relationships of viral and protozoal co-infections to Chlamydia pecorum infection and chlamydiosis outcomes in northern koalas (Phascolarctos cinereus).PLoS pathogens · 2025Article
- Dominance of Vaccine-SpecificEcology and evolution · 2025Article
- Comparative analysis of two genomes of Chlamydia pecorum isolates from an Alpine chamois and a water buffalo.BMC genomics · 2022Article
- Chlamydial species among wild birds and livestock in the foothills of Mt. Afadjato, Ghana.The Journal of veterinary medical science · 2022Article
- Genetic diversity of Chlamydia pecorum detected in sheep flocks from Mexico.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Chlamydia pecorum detection in aborted and stillborn lambs from Western Australia.Veterinary research · 2021Article
- Koala immunogenetics and chlamydial strain type are more directly involved in chlamydial disease progression in koalas from two south east Queensland koala populations than koala retrovirus subtypes.Scientific reports · 2020Article
- Helping koalas battle disease - Recent advances in Chlamydia and koala retrovirus (KoRV) disease understanding and treatment in koalas.FEMS microbiology reviews · 2020Review
- A novel synthetic peptide microarray assay detects Chlamydia species-specific antibodies in animal and human sera.Scientific reports · 2018Article
- Molecular and serological dynamics ofPeerJ · 2018Article
- Clinical, diagnostic and pathologic features of presumptive cases of Chlamydia pecorum-associated arthritis in Australian sheep flocks.BMC veterinary research · 2016Article
- Chlamydia gallinacea, not C. psittaci, is the endemic chlamydial species in chicken (Gallus gallus).Scientific reports · 2016Article
- Article
- Identification and characterization of a novel stress-responsive outer membrane protein Lip40 from Actinobacillus pleuropneumoniae.BMC biotechnology · 2015Article
- Genetic diversity in the plasticity zone and the presence of the chlamydial plasmid differentiates Chlamydia pecorum strains from pigs, sheep, cattle, and koalas.BMC genomics · 2015Article
- Defining species-specific immunodominant B cell epitopes for molecular serology of Chlamydia species.Clinical and vaccine immunology : CVI · 2015Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chlamydia (C.) pecorum, an obligate intracellular bacterium, may cause severe diseases in ruminants, swine and koalas, although asymptomatic infections are the norm. Recently, we identified genetic polymorphisms in the ompA, incA and ORF663 genes that potentially differentiate between high-virulence C. pecorum isolates from diseased animals and low-virulence isolates from asymptomatic animals. Here, we expand these findings by including additional ruminant, swine, and koala strains. Coding tandem repeats (CTRs) at the incA locus encoded a variable number of repeats of APA or AGA amino acid motifs. Addition of any non-APA/AGA repeat motif, such as APEVPA, APAVPA, APE, or APAPE, associated with low virulence (P<10-4), as did a high number of amino acids in all incA CTRs (P = 0.0028). In ORF663, high numbers of 15-mer CTRs correlated with low virulence (P = 0.0001). Correction for ompA phylogram position in ORF663 and incA abolished the correlation between genetic changes and virulence, demonstrating co-evolution of ompA, incA, and ORF663 towards low virulence. Pairwise divergence of ompA, incA, and ORF663 among isolates from healthy animals was significantly higher than among strains isolated from diseased animals (P≤10-5), confirming the longer evolutionary path traversed by low-virulence strains. All three markers combined identified 43 unique strains and 4 pairs of identical strains among all 57 isolates tested, demonstrating the suitability of these markers for epidemiological investigations.
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