ArticlePloS one2014
Soluble α-klotho as a novel biomarker in the early stage of nephropathy in patients with type 2 diabetes.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Relationship of Soluble Klotho and Early Stage of Diabetic Nephropathy: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2022Pooled it
- Soluble Klotho Is Decreased in Children With Type 1 Diabetes and Correlated With Metabolic Control.Frontiers in endocrinology · 2021Trial
- Association between the serum Klotho levels and diabetic kidney disease: results from the NHANES 2007-2016 and Mendelian randomization study.Journal of diabetes and metabolic disorders · 2025Article
- Fetuin-A and Heme Oxygenase 1 as Potential New Markers in the Diagnosis of Diabetic Kidney Disease.International journal of molecular sciences · 2025Review
- Associations of serum Klotho with diabetic kidney disease prevalence and mortality: insights from a nationally representative U.S. cohort.Diabetology & metabolic syndrome · 2025Article
- Klotho in diabetes mellitus: research progress and clinical implications.Frontiers in endocrinology · 2025Review
- Association of serum klotho level with albuminuria in middle‑aged and elderly participants without diabetes mellitus: a cross‑sectional study.BMC nephrology · 2024Article
- Association between the duration of smoking cessation and α-Klotho levels in the US middle-aged and elderly population.Heliyon · 2024Article
- Serum soluble α-Klotho levels in patients with diabetic nephropathy.Irish journal of medical science · 2024Article
- Klotho Stabilizes the Podocyte Actin Cytoskeleton in Idiopathic Membranous Nephropathy through Regulating the TRPC6/CatL Pathway.American journal of nephrology · 2024Article
- PKC regulates αKlotho gene expression in MDCK and NRK-52E cells.Pflugers Archiv : European journal of physiology · 2024Article
- Article
- An evaluation of both serum Klotho/FGF-23 and apelin-13 for detection of diabetic nephropathy.Hormones (Athens, Greece) · 2023Article
- Association of Klotho with Coronary Artery Disease in Subjects with Type 2 Diabetes Mellitus and Preserved Kidney Function: A Case-Control Study.International journal of molecular sciences · 2023Article
- Potential application of Klotho as a prognostic biomarker for patients with diabetic kidney disease: a meta-analysis of clinical studies.Therapeutic advances in chronic disease · 2023Article
- Disease predictability review using common biomarkers appearing in diabetic nephropathy and neurodegeneration of experimental animals.Laboratory animal research · 2022Review
- Association between serum Klotho levels and the prevalence of diabetes among adults in the United States.Frontiers in endocrinology · 2022Article
- Klotho and SIRT1 changes from pre-diabetes to diabetes and pre-hypertension to hypertension.Diabetology & metabolic syndrome · 2021Article
- Soluble Alpha Klotho in Acromegaly: Comparison With Traditional Markers of Disease Activity.The Journal of clinical endocrinology and metabolism · 2021Article
- Klotho prevents epithelial-mesenchymal transition through Egr-1 downregulation in diabetic kidney disease.BMJ open diabetes research & care · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAlthough α-klotho is known as an anti-aging, antioxidant, and cardio-renal protective protein, the clinical implications of soluble α-klotho levels in patients with diabetes have not been evaluated. Therefore, this study evaluated whether plasma and urinary α-klotho levels are associated with albuminuria in kidney disease in diabetes. RESEARCH DESIGN AND
methodsA total of 147 patients with type 2 diabetes and 25 healthy control subjects were enrolled. The plasma and urine concentrations of α-klotho were analyzed by enzyme-linked immunosorbent assay.
resultsPlasma α-klotho (572.4 pg/mL [95% CI, 541.9-604.6 pg/mL] vs. 476.9 pg/mL [95% CI, 416.9-545.5 pg/mL]) and urinary α-klotho levels (59.8 pg/mg creatinine [95% CI, 43.6-82.0 pg/mg creatinine] vs. 21.0 pg/mg creatinine [95% CI, 9.7-45.6 pg/mg creatinine]) were significantly higher in diabetic patients than non-diabetic controls. Among diabetic patients, plasma α-klotho concentration was inversely associated with albuminuria stages (normoalbuminuria, 612.6 pg/mL [95% CI, 568.9-659.6 pg/mL], microalbuminuria, 551.8 pg/mL [95% CI, 500.5-608.3 pg/mL], and macroalbuminuria, 505.7 pg/mL [95% CI, 439.7-581.7 pg/mL] (p for trend = 0.0081), while urinary α-klotho levels were remained constantly high with increasing urinary albumin excretion.
conclusionsSoluble α-klotho levels in plasma and urine may be novel and useful early markers of diabetic renal injury.
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