Evidence map›Paper›PMID 25083504›Full record

ReviewGland surgery2014

Intraoperative radiotherapy for breast cancer.

Norman R Williams, Katharine H Pigott, Chris Brew-Graves, Mohammed R S Keshtgar

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gland surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. New era of electronic brachytherapy.World journal of radiology · 2017
    Article
  8. Journal of venom research · 2017
    Article
  9. Intraoperative radiation therapy deserves to be made more readily available to patients.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2016
    Article
  10. Combined Runx2 and Snail overexpression is associated with a poor prognosis in breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Norman R Williams1 Clinical Trials Group, Division of Surgery & Interventional Science, Faculty of Medical Sciences, University College London, London, W1W 7EJ, UK ; 2 Radiotherapy Department, 3 The Breast Unit, Royal Free London Foundation Trust, University College London, Hampstead NW3 2QG, UK.
Katharine H Pigott1 Clinical Trials Group, Division of Surgery & Interventional Science, Faculty of Medical Sciences, University College London, London, W1W 7EJ, UK ; 2 Radiotherapy Department, 3 The Breast Unit, Royal Free London Foundation Trust, University College London, Hampstead NW3 2QG, UK.
Chris Brew-Graves1 Clinical Trials Group, Division of Surgery & Interventional Science, Faculty of Medical Sciences, University College London, London, W1W 7EJ, UK ; 2 Radiotherapy Department, 3 The Breast Unit, Royal Free London Foundation Trust, University College London, Hampstead NW3 2QG, UK.
Mohammed R S Keshtgar1 Clinical Trials Group, Division of Surgery & Interventional Science, Faculty of Medical Sciences, University College London, London, W1W 7EJ, UK ; 2 Radiotherapy Department, 3 The Breast Unit, Royal Free London Foundation Trust, University College London, Hampstead NW3 2QG, UK.
University College London · GB

Funding

Department of Health 07/60/49Department of Health 10/104/07
6 · The paper itself

Abstract

Intra-operative radiotherapy (IORT) as a treatment for breast cancer is a relatively new technique that is designed to be a replacement for whole breast external beam radiotherapy (EBRT) in selected women suitable for breast-conserving therapy. This article reviews twelve reasons for the use of the technique, with a particular emphasis on targeted intra-operative radiotherapy (TARGIT) which uses X-rays generated from a portable device within the operating theatre immediately after the breast tumour (and surrounding margin of healthy tissue) has been removed. The delivery of a single fraction of radiotherapy directly to the tumour bed at the time of surgery, with the capability of adding EBRT at a later date if required (risk-adaptive technique) is discussed in light of recent results from a large multinational randomised controlled trial comparing TARGIT with EBRT. The technique avoids irradiation of normal tissues such as skin, heart, lungs, ribs and spine, and has been shown to improve cosmetic outcome when compared with EBRT. Beneficial aspects to both institutional and societal economics are discussed, together with evidence demonstrating excellent patient satisfaction and quality of life. There is a discussion of the published evidence regarding the use of IORT twice in the same breast (for new primary cancers) and in patients who would never be considered for EBRT because of their special circumstances (such as the frail, the elderly, or those with collagen vascular disease). Finally, there is a discussion of the role of the TARGIT Academy in developing and sustaining high standards in the use of the technique.

Indexed as

Early breast cancerIntrabeamintra-operative radiotherapy (IORT)radiotherapytargeted intra-operative radiotherapy (TARGIT)

Identifiers

PMID25083504
PMCPMC4115764
OpenAlexW1730202382

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.