Evidence map›Paper›PMID 25083424›Full record

ArticleGland surgery2012

Expressions of D2-40, CK19, galectin-3, VEGF and EGFR in papillary thyroid carcinoma.

Lei Gong, Ping Chen, Xianjun Liu, Ying Han, Yanping Zhou, Weidong Zhang, Hong Li, Chuanjia Li, Jiang Xie

Open access · greenAbstract read
In one paragraph

Article in Gland surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. CircRNA circ_0067934 Overexpression Correlates with Poor Prognosis and Promotes Thyroid Carcinoma Progression.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
  5. Article
  6. Article
  7. Article
  8. Diagnostic accuracy of CK-19, Galectin-3 and HBME-1 on papillary thyroid carcinoma: a meta-analysis.International journal of clinical and experimental pathology · 2017
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lei GongDepartment of Pathology, the Central Hospital of Jilin City, Jilin 132011, China.
Ping ChenDepartment of Pathology, the Central Hospital of Jilin City, Jilin 132011, China.
Xianjun LiuDepartment of Pathology, the Central Hospital of Jilin City, Jilin 132011, China.
Ying HanDepartment of Pathology, the Central Hospital of Jilin City, Jilin 132011, China.
Yanping ZhouDepartment of Pathology, the Central Hospital of Jilin City, Jilin 132011, China.
Weidong ZhangDepartment of Pathology, the Central Hospital of Jilin City, Jilin 132011, China.
Hong LiDepartment of Pathology, the Central Hospital of Jilin City, Jilin 132011, China.
Chuanjia LiDepartment of Pathology, the Central Hospital of Jilin City, Jilin 132011, China.
Jiang XieDepartment of Pathology, the Central Hospital of Jilin City, Jilin 132011, China.
Jilin City Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the expressions of D2-40, CK19, galectin-3, VEGF, and EGFR in papillary thyroid carcinoma and their clinical significances.

methodsThe expressions of D2-40, CK19, galectin-3, VEGF, and EGFR in 38 cases of papillary thyroid carcinoma and 12 cases of thyroid papillary hyperplasia were detected by immunohistochemical staining.

resultsThe positive expression rates of D2-40, CK19, Galectin-3, VEGF and EGFR in patients with papillary thyroid carcinoma were all significantly higher than those in patients with thyroid papillary hyperplasia (all P<0.05). The expressions of D2-40, VEGF, and EGFR in papillary thyroid carcinoma with lymph node metastasis were significantly higher than those without lymph node metastasis (P<0.05). The expressions of GK19 and galectin-3 showed no significant differences between the papillary thyroid carcinomas with and without lymph node metastasis (P>0.05).

conclusionsThe detection of D2-40, CK19, galectin-3, VEGF, and EGFR is helpful for the diagnosis and differential diagnosis of papillary thyroid carcinoma and thyroid papillary hyperplasia.

Indexed as

CK19D2-40EGFRgalectin-3immunohistochemispapillary carcinomaThyroid neoplasmsVEGF

Identifiers

PMID25083424
PMCPMC4115709
OpenAlexW184454327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.