ReviewTherapeutic advances in drug safety2014
Medication-overuse headache: epidemiology, diagnosis and treatment.
Review in Therapeutic advances in drug safety, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 7 syntheses or guidelines pooled it, 174 citations in OpenAlex.
- Effect of Educational and Behavioral Interventions on Medication-Overuse Headache: A Systematic Review and Meta-Analysis.Pain research & management · 2026Pooled it
- The global prevalence of headache disorders of public-health importance: a meta-analysis of population-based individual participant data from 41,614 adults from 17 countries.The journal of headache and pain · 2025Pooled it
- Safety, efficacy, and compliance of moderate-to-high dose eptinezumab and erenumab in chronic migraine patients with medication-overuse headache: an updated systematic review and meta-analysis.The journal of headache and pain · 2025Pooled it
- Network meta-analysis comparing efficacy of different strategies on medication-overuse headache.The journal of headache and pain · 2025Pooled it
- Efficacy and safety of onabotulinumtoxinA in the treatment of medication overuse headache: a systematic review.Frontiers in neurology · 2024Pooled it
- The burden of medication overuse headache and patterns of switching and discontinuation among triptan users: a systematic literature review.BMC neurology · 2021Pooled it
- Effectiveness of transcutaneous electrical nerve stimulation for the treatment of migraine: a meta-analysis of randomized controlled trials.The journal of headache and pain · 2018Pooled it
- Eptinezumab With Patient Education for Chronic Migraine and Medication-Overuse Headache: The Randomized, Placebo-Controlled RESOLUTION Trial.Neurology · 2026Trial
- Intracranial pressure directly predicts headache morbidity in idiopathic intracranial hypertension.The journal of headache and pain · 2021Trial
- Treatment benefit among migraine patients taking fremanezumab: results from a post hoc responder analysis of two placebo-controlled trials.The journal of headache and pain · 2021Trial
- The impact of fremanezumab on medication overuse in patients with chronic migraine: subgroup analysis of the HALO CM study.The journal of headache and pain · 2020Trial
- Biofeedback in the prophylactic treatment of medication overuse headache: a pilot randomized controlled trial.The journal of headache and pain · 2016Trial
- Illness Perception and its Association with Emotional Distress Among Adults with Migraine: A Cross-Sectional Study.Journal of epidemiology and global health · 2026Article
- Current landscape of migraine care with expert consensus from East Asia.The journal of headache and pain · 2026Review
- Hypochondriasis, somatic amplification, and pain beliefs in patients with medication overuse headache.Arquivos de neuro-psiquiatria · 2026Article
- Awareness, attitudes, and clinical practices related to medication-overuse headache among Italian pharmacists: results from a cross-sectional survey.The journal of headache and pain · 2026Article
- Medication Overuse Headache and Health-Related Quality of Life for Adults with Migraine in Saudi Arabia.Journal of clinical medicine · 2026Article
- Endocannabinoid Modulation in Headache: Mechanisms, Models, and Translational Therapies.Cells · 2026Review
- Vestibular Migraine-Like Syndrome in a Patient With Postttraumatic Headache and Medication-Overuse Headache.Case reports in otolaryngology · 2026Article
- Assessing Self-medication Practices Among Healthcare Providers With Migraine in Saudi Arabia.Brain and behavior · 2025Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medication-overuse headache (MOH) is one of the most common chronic headache disorders and a public health problem with a worldwide prevalence of 1-2%. It is a condition characterized by chronic headache and overuse of different headache medications, and withdrawal of the overused medication is recognised as the treatment of choice. However, the strategy for achieving withdrawal is, at present, based on expert opinion rather than scientific evidence, partly due to the lack of randomised controlled studies. This narrative review investigates different aspects of epidemiology, diagnosis, risk factors and pathogenesis as well as management for MOH. We suggest that the first step in the treatment of MOH should be carried out in general practice and should focus primarily on detoxification. For most patients, both prevention and follow up after detoxification can also be performed in general practice, thus freeing resources for referral of more complicated cases to headache clinics and neurologists. These suffering patients have much to gain by an earlier treatment-focused approach lower down on the treatment ladder.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.