ReviewTherapeutic advances in drug safety2011
Current issues on safety of prokinetics in critically ill patients with feed intolerance.
Review in Therapeutic advances in drug safety, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- ACG Clinical Guideline: Nutrition Therapy in the Adult Hospitalized Patient.The American journal of gastroenterology · 2016Guideline
- Use of Prokinetic Agents in Adult ICU Patients: An International Inception Cohort Study (PATIENCE).Acta anaesthesiologica Scandinavica · 2026Article
- An evaluation based on explainable machine learning: analysis of risk factors for enteral nutrition-related diarrhea in patients with severe stroke.Frontiers in nutrition · 2026Article
- Selected Serious Adverse Events in a Cohort of Adult ICU Patients: Protocol for a Sub-Study of the PATIENCE Cohort.Acta anaesthesiologica Scandinavica · 2025Article
- Preferences on the Use of Prokinetic Agents in Adult Intensive Care Unit Patients-An International Survey.Acta anaesthesiologica Scandinavica · 2025Article
- Prokinetic effect of erythromycin in the management of gastroparesis in critically ill patients-our experience and literature review.Frontiers in medicine · 2024Review
- Optimal dose and duration of enteral erythromycin as a prokinetic: A surgical intensive care experience.Qatar medical journal · 2020Article
- Effects of Drugs and Excipients on Hydration Status.Nutrients · 2019Review
- Symptom burden in heart failure: assessment, impact on outcomes, and management.Heart failure reviews · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Feed intolerance in the setting of critical illness should be treated promptly given its adverse impact on morbidity and mortality. The technical difficulty of postpyloric feeding tube placement and the morbidities associated with parenteral nutrition prevent these approaches being considered as first-line nutrition. Prokinetic agents are currently the mainstay of therapy for feed intolerance in the critically ill. Current information is limited but suggests that erythromycin or metoclopramide (alone or in combination) are effective in the management of feed intolerance in the critically ill and not associated with significant cardiac, haemodynamic or neurological adverse effects. However, diarrhoea is a very common gastrointestinal side effect, and can occur in up to 49% of patients who receive both erythromycin and metoclopramide. Fortunately, the diarrhoea associated with prokinetic treatments has not been linked to Clostridium difficile infection and settles soon after the drugs are ceased. Therefore, prolonged or prophylactic use of prokinetics should be avoided. If diarrhoea occurs, the drugs should be stopped immediately. To minimize avoidable adverse effects the ongoing need for prokinetic drugs in these patient should be reviewed daily.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.