ArticleVirchows Archiv. A, Pathological anatomy and histopathology1989
Colonic pericryptal fibroblasts. Differentiation pattern in embryogenesis and phenotypic modulation in epithelial proliferative lesions.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 85 citations in OpenAlex.
- Myofibroblasts are distinguished from activated skin fibroblasts by the expression of AOC3 and other associated markers.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Mesenchymal-epithelial interactions during digestive tract development and epithelial stem cell regeneration.Cellular and molecular life sciences : CMLS · 2015Review
- Vasculo-smooth muscle hamartomatous structure is linked to morphogenesis of colorectal polypoid adenoma.Medical molecular morphology · 2015Article
- Role of stromal-epithelial interaction in the formation and development of cancer cells.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2013Article
- Mechanoregulation of the Myofibroblast in Wound Contraction, Scarring, and Fibrosis: Opportunities for New Therapeutic Intervention.Advances in wound care · 2013Review
- Expression of podoplanin/D2-40 in pericryptal stromal cells in superficial colorectal epithelial neoplasia.Medical molecular morphology · 2013Article
- Stromal cells in the human gut show ultrastructural features of fibroblasts and smooth muscle cells but not myofibroblasts.Journal of cellular and molecular medicine · 2011Article
- Intestinal myofibroblasts: targets for stem cell therapy.American journal of physiology. Gastrointestinal and liver physiology · 2011Review
- Colonic subepithelial myofibroblasts in mucosal inflammation and repair: contribution of bone marrow-derived stem cells to the gut regenerative response.Journal of gastroenterology · 2005Review
- Mutual paracrine effects of colorectal tumour cells and stromal cells: modulation of tumour and stromal cell differentiation and extracellular matrix component production in culture.International journal of experimental pathology · 2005Article
- The gastrointestinal stem cell.Cell proliferation · 2004Review
- P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast phenotype.The Journal of clinical investigation · 2002Article
- Alpha smooth muscle actin positive stromal cells in gastric carcinoma.Journal of clinical pathology · 2002Article
- c-MET expression in myofibroblasts: role in autocrine activation and prognostic significance in lung adenocarcinoma.The American journal of pathology · 2001Article
- Differential expression of CD34 in normal colorectal tissue, peritumoral inflammatory tissue, and tumour stroma.Journal of clinical pathology · 2000Article
- Myofibroblasts: paracrine cells important in health and disease.Transactions of the American Clinical and Climatological Association · 2000Review
- Differential expression of high molecular weight caldesmon in colorectal pericryptal fibroblasts and tumour stroma.Journal of clinical pathology · 1999Article
- Review
- In situ stromal expression of the urokinase/plasmin system correlates with epithelial dysplasia in colorectal adenomas.The American journal of pathology · 1997Article
- The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells.The Journal of clinical investigation · 1995Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experimental evidence has shown that fetal gut mesenchymal cells can modulate epithelial cell differentiation. It is postulated that reciprocal stromal-epithelial interactions in the digestive tract are maintained beyond embryonic life. The mature colonic mucosa contains pericryptal fibroblasts (PCF), a stromal cell type exhibiting smooth muscle morphological features, which are thought to regulate the growth and differentiation of adjacent epithelial cells. Using an antibody directed at alpha-smooth muscle actin, which is constantly expressed in smooth muscle cells, we performed an immuno-histochemical study on human embryonic tissues to assess PCF differentiation during development. PCF expressing alpha-smooth muscle actin were first detected around the 21st week of gestation, at the bases of the crypts; the number of differentiated PCF increased then progressively, in synchrony with epithelial proliferation, to achieve at birth the characteristic distribution found in adults. We analyzed a series of non-malignant and malignant epithelial proliferative lesions of the adult colon by the same technique. Only sparse immunoreactive PCF were observed in 10/10 pure tubular adenomas, whereas in 11/11 villous adenomas immunoreactive PCF were consistently found bordering proliferative epithelia. Interestingly, 3/5 papillary adenomas, associated with areas of moderate to marked dysplasia, demonstrated foci of multilayered immunoreactive PCF. In 14/14 carcinomas examined, PCF were no longer recognizable; stromal cells expressing variable amounts of alpha-smooth muscle actin, constituting the desmoplastic reaction, were constantly present. These observations establish immunohistochemically a smooth muscle phenotypic feature of PCF, which is acquired at mid-gestation, and the ability of PCF to proliferate in conjunction with some epithelial neoplasias. These findings might help to clarify the histogenesis of PCF and to improve our understanding of the mesenchymal-epithelial interactions suspected to operate during organogenesis as well as benign and malignant neoplastic conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.