ArticleSleep2014
The dynamics of cortical neuronal activity in the first minutes after spontaneous awakening in rats and mice.
Article in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Sleep and experience-dependent visual plasticity in the adult cerebral cortex: an update.Sleep · 2025Article
- Cortical activity upon awakening from sleep reveals consistent spatio-temporal gradients across sleep stages in human EEG.Current biology : CB · 2025Article
- Traces of EEG-fMRI coupling reveals neurovascular dynamics on sleep inertia.Scientific reports · 2024Article
- Regional variability in intracerebral properties of NREM to REM sleep transitions in humans.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Neuronal-spiking-based closed-loop stimulation during cortical ON- and OFF-states in freely moving mice.Journal of sleep research · 2022Article
- A temporal sequence of thalamic activity unfolds at transitions in behavioral arousal state.Nature communications · 2022Article
- An Exploration of Self-Reported Sleep Inertia Symptoms Using Network Analysis.Nature and science of sleep · 2022Article
- Dynamics of hippocampus and orbitofrontal cortex activity during arousing reactions from sleep: An intracranial electroencephalographic study.Human brain mapping · 2021Article
- A novel bedtime pulsatile-release caffeine formula ameliorates sleep inertia symptoms immediately upon awakening.Scientific reports · 2021Article
- Article
- The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia.Frontiers in neuroscience · 2021Article
- Global sleep homeostasis reflects temporally and spatially integrated local cortical neuronal activity.eLife · 2020Article
- Regional Delta Waves In Human Rapid Eye Movement Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Sleep inertia: current insights.Nature and science of sleep · 2019Article
- Harnessing olfactory bulb oscillations to perform fully brain-based sleep-scoring and real-time monitoring of anaesthesia depth.PLoS biology · 2018Article
- Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Review
- Waking up is the hardest thing I do all day: Sleep inertia and sleep drunkenness.Sleep medicine reviews · 2017Review
- Local aspects of sleep and wakefulness.Current opinion in neurobiology · 2017Review
- Stereotypic wheel running decreases cortical activity in mice.Nature communications · 2016Article
- Lempel-Ziv complexity of cortical activity during sleep and waking in rats.Journal of neurophysiology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
STUDY
objectiveUpon awakening from sleep, a fully awake brain state is not reestablished immediately, but the origin and physiological properties of the distinct brain state during the first min after awakening are unclear. To investigate whether neuronal firing immediately upon arousal is different from the remaining part of the waking episode, we recorded and analyzed the dynamics of cortical neuronal activity in the first 15 min after spontaneous awakenings in freely moving rats and mice.
designIntracortical recordings of the local field potential and neuronal activity in freely-moving mice and rats.
settingBasic sleep research laboratory. PATIENTS OR
participantsWKY adult male rats, C57BL/6 adult male mice.
interventionsN/A. MEASUREMENTS AND
resultsIn both species the average population spiking activity upon arousal was initially low, though substantial variability in the dynamics of firing activity was apparent between individual neurons. A distinct population of neurons was found that was virtually silent in the first min upon awakening. The overall lower population spiking initially after awakening was associated with the occurrence of brief periods of generalized neuronal silence (OFF periods), whose frequency peaked immediately after awakening and then progressively declined. OFF periods incidence upon awakening was independent of ongoing locomotor activity but was sensitive to immediate preceding sleep/wake history. Notably, in both rats and mice if sleep before a waking episode was enriched in rapid eye movement sleep, the incidence of OFF periods was initially higher as compared to those waking episodes preceded mainly by nonrapid eye movement sleep.
conclusionWe speculate that an intrusion of sleep-like patterns of cortical neuronal activity into the wake state immediately after awakening may account for some of the changes in the behavior and cognitive function typical of what is referred to as sleep inertia. CITATION: Vyazovskiy VV, Cui N, Rodriguez AV, Funk C, Cirelli C, Tononi G. The dynamics of cortical neuronal activity in the first minutes after spontaneous awakening in rats and mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.