ArticleSleep2014
Stress and sleep reactivity: a prospective investigation of the stress-diathesis model of insomnia.
Article in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
150 citing papers in PubMed, 6 syntheses or guidelines pooled it, 339 citations in OpenAlex.
- Convergent abnormality in the subgenual anterior cingulate cortex in insomnia disorder: A revisited neuroimaging meta-analysis of 39 studies.Sleep medicine reviews · 2023Pooled it
- Influencing factors of sleep disorders and sleep quality in healthcare workers during the COVID-19 pandemic: A systematic review and meta-analysis.Nursing open · 2023Pooled it
- Sleep Problems and Workplace Violence: A Systematic Review and Meta-Analysis.Frontiers in neuroscience · 2019Pooled it
- Association between insomnia and job stress: a meta-analysis.Sleep & breathing = Schlaf & Atmung · 2018Pooled it
- Insomnia as a Precipitating Factor in New Onset Mental Illness: a Systematic Review of Recent Findings.Current psychiatry reports · 2017Pooled it
- Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.Journal of evidence-based integrative medicinePooled it
- Modulating stress and sleep through a multi-compound dietary supplement: a randomized, double-blind, placebo-controlled trial.Journal of the International Society of Sports Nutrition · 2026Trial
- Efficacy of electrical vestibular stimulation (VeNS) on adults with insomnia: A double-blind, randomized, sham-controlled trial.Dialogues in clinical neuroscience · 2025Trial
- Short-time resistance training enhances sleep quality in obese and non-obese young women.Sleep & breathing = Schlaf & Atmung · 2025Trial
- How Does E-mail-Delivered Cognitive Behavioral Therapy Work for Young Adults (18-28 Years) with Insomnia? Mediators of Changes in Insomnia, Depression, Anxiety, and Stress.International journal of environmental research and public health · 2022Trial
- Can an E-Mail-Delivered CBT for Insomnia Validated in the West Be Effective in the East? A Randomized Controlled Trial.International journal of environmental research and public health · 2021Trial
- Sleep moderates the relationship between stress and craving in individuals with opioid use disorder.Experimental and clinical psychopharmacology · 2021Trial
- Effects of a Tailored Brief Behavioral Therapy Application on Insomnia Severity and Social Disabilities Among Workers With Insomnia in Japan: A Randomized Clinical Trial.JAMA network open · 2020Trial
- Acute stress alters autonomic modulation during sleep in women approaching menopause.Psychoneuroendocrinology · 2016Trial
- Sleep microstructure correlates of the first-night effect: sleep spindles and slow-wave activity in healthy adults.Sleep & breathing = Schlaf & Atmung · 2026Article
- Sleep Reactivity Amplifies the Impact of Pre-Sleep Cognitive Arousal on Sleep Disturbances.Journal of sleep research · 2026Article
- Insomnia and women: exploring vulnerability, impact, and intervention.Sleep & breathing = Schlaf & Atmung · 2026Review
- Sleep fragmentation intensifies sleep architecture disruption and fatigue after traumatic brain injury.Experimental neurology · 2026Article
- Associations between pain reactivity to worse sleep and health outcomes.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Personalized resilience: how individual variability in brain-immune responses to stress influences the development of anxiety disorders.Frontiers in cellular neuroscience · 2026Review
90 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectivesTo prospectively assess sleep reactivity as a diathesis of insomnia, and to delineate the interaction between this diathesis and naturalistic stress in the development of insomnia among normal sleepers.
designLongitudinal.
settingCommunity-based.
participants2,316 adults from the Evolution of Pathways to Insomnia Cohort (EPIC) with no history of insomnia or depression (46.8 ± 13.2 y; 60% female).
interventionsNone. MEASUREMENTS AND
resultsParticipants reported the number of stressful events they encountered at baseline (Time 1), as well as the level of cognitive intrusion they experienced in response to each stressor. Stressful events (OR = 1.13; P < 0.01) and stress-induced cognitive intrusion (OR = 1.61; P < 0.01) were significant predictors of risk for insomnia one year hence (Time 2). Intrusion mediated the effects of stressful events on risk for insomnia (P < 0.05). Trait sleep reactivity significantly increased risk for insomnia (OR = 1.78; P < 0.01). Further, sleep reactivity moderated the effects of stress-induced intrusion (P < 0.05), such that the risk for insomnia as a function of intrusion was significantly higher in individuals with high sleep reactivity. Trait sleep reactivity also constituted a significant risk for depression (OR = 1.67; P < 0.01) two years later (Time 3). Insomnia at Time 2 significantly mediated this effect (P < 0.05).
conclusionsThis study suggests that premorbid sleep reactivity is a significant risk factor for incident insomnia, and that it triggers insomnia by exacerbating the effects of stress-induced intrusion. Sleep reactivity is also a precipitant of depression, as mediated by insomnia. These findings support the stress-diathesis model of insomnia, while highlighting sleep reactivity as an important diathesis. CITATION: Drake CL, Pillai V, Roth T. Stress and sleep reactivity: a prospective investigation of the stress-diathesis model of insomnia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.