Evidence map›Paper›PMID 25082854›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2014

Imaging the evolution of reactivation pulmonary tuberculosis in mice using 18F-FDG PET.

Allison M Murawski, Saumya Gurbani, Jamie S Harper, Mariah Klunk, Laurent Younes, Sanjay K Jain, Bruno M Jedynak

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
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  8. [ACS infectious diseases · 2018
    Article
  9. Review
  10. A Systematic Approach for Developing Bacteria-Specific Imaging Tracers.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2017
    Article
  11. Review
  12. PET/CT in nononcological lung diseases: current applications and future perspectives.European respiratory review : an official journal of the European Respiratory Society · 2016
    Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Allison M MurawskiCenter for Infection and Inflammation Imaging Research, Johns Hopkins University, Baltimore, Maryland Center for Tuberculosis Research, Johns Hopkins University, Baltimore, Maryland Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland sjain5@jhmi.edu.
Saumya GurbaniDepartment of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, Maryland and Center for Imaging Science, Johns Hopkins University, Baltimore, Maryland.
Jamie S HarperCenter for Infection and Inflammation Imaging Research, Johns Hopkins University, Baltimore, Maryland Center for Tuberculosis Research, Johns Hopkins University, Baltimore, Maryland Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland sjain5@jhmi.edu.
Mariah KlunkCenter for Infection and Inflammation Imaging Research, Johns Hopkins University, Baltimore, Maryland Center for Tuberculosis Research, Johns Hopkins University, Baltimore, Maryland Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland.
Laurent YounesDepartment of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, Maryland and Center for Imaging Science, Johns Hopkins University, Baltimore, Maryland.
Sanjay K JainCenter for Infection and Inflammation Imaging Research, Johns Hopkins University, Baltimore, Maryland Center for Tuberculosis Research, Johns Hopkins University, Baltimore, Maryland Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland sjain5@jhmi.edu.
Bruno M JedynakDepartment of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, Maryland and Center for Imaging Science, Johns Hopkins University, Baltimore, Maryland.
Johns Hopkins University · US

Funding

Novel imaging biomarkers to address fundamental controversies in TB pathogenesisDP2OD006492 · OD · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2009 to 2014
$2.9M
Molecular Imaging for Macrophage-Associated Pulmonary InflammationR01HL116316 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2012 to 2014
$1.2M
NHLBI NIH HHS R01 HL116316NHLBI NIH HHS R01-HL116316-01NIH HHS DP2 OD006492NIH HHS DP2-OD006492-01
6 · The paper itself

Abstract

unlabelledLatent tuberculosis infection affects one third of the world's population and can reactivate (relapse) decades later. However, current technologies, dependent on postmortem analyses, cannot follow the temporal evolution of disease.

methodsC3HeB/FeJ mice, which develop necrotic and hypoxic tuberculosis lesions, were aerosol-infected with Mycobacterium tuberculosis. PET and CT were used to serially image the same cohort of infected mice through pretreatment, tuberculosis treatment, and subsequent development of relapse.

resultsA novel diffeomorphic registration was successfully used to monitor the spatial evolution of individual pulmonary lesions. Although most lesions during relapse developed in the same regions as those noted during pretreatment, several lesions also arose de novo within regions with no prior lesions.

conclusionThis study presents a novel model that simulates infection and reactivation disease as seen in humans and could prove valuable to study tuberculosis pathogenesis and evaluate novel therapeutics.

Indexed as

Fluorodeoxyglucose F18AnimalsAntitubercular AgentsDisease Models, AnimalFemaleLungMiceMice, Inbred C3HMycobacterium tuberculosisPositron-Emission TomographyRadiopharmaceuticalsRecurrenceTomography, X-Ray ComputedTuberculosis, PulmonaryAntitubercular AgentsFluorodeoxyglucose F18Radiopharmaceuticalsdiffeomorphic registrationlatentmousereactivationtuberculosis

Identifiers

PMID25082854
PMCPMC4486060
OpenAlexW2128693605

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.