Evidence map›Paper›PMID 25082585›Full record

ReviewJournal of the American College of Cardiology2014

D-transposition of the great arteries: the current era of the arterial switch operation.

Juan Villafañe, M Regina Lantin-Hermoso, Ami B Bhatt, James S Tweddell, Tal Geva, Meena Nathan, Martin J Elliott, Victoria L Vetter, Stephen M Paridon, Lazaros Kochilas and 5 more

Abstract readReview
In one paragraph

Review in Journal of the American College of Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 1 pooled it
17.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 1 synthesis or guideline pooled it, 283 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Resilience in families of children with dextro-transposition of the great arteries.Journal of perinatology : official journal of the California Perinatal Association · 2026
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 2 countries.

Juan VillafañeDepartment of Pediatrics (Cardiology), University of Kentucky, Lexington, Kentucky. Electronic address: juanvillaf@yahoo.com.
M Regina Lantin-HermosoPediatric Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.
Ami B BhattAdult Congenital Heart Disease Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
James S TweddellCardiothoracic Surgery, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin.
Tal GevaDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Meena NathanDepartment of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Martin J ElliottDepartment of Pediatric Cardiothoracic Surgery, The Great Ormond Street Hospital for Children, NHS Foundation Trust, London, United Kingdom.
Victoria L VetterChildren's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Stephen M ParidonDepartment of Exercise Physiology, Perlman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Lazaros KochilasUniversity of Minnesota Children's Hospital, Minneapolis, Minnesota.
Kathy J JenkinsBoston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Robert H BeekmanDivision of Cardiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Gil WernovskyThe Heart Program, Miami Children's Hospital, Florida International University Herbert Wertheim College of Medicine, Miami, Florida.
Jeffrey A TowbinThe Heart Institute, Division of Cardiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
American College of Cardiology’s Adult Congenital and Pediatric Cardiology Council
Boston Children's Hospital · USCincinnati Children's Hospital Medical Center · USBaylor College of Medicine · USChildren's Hospital of Philadelphia · USChildren's Hospital of Wisconsin · USFlorida International University · USGreat Ormond Street Hospital for Children NHS Foundation Trust · GBHarvard University · USUniversity of Kentucky · USUniversity of Minnesota · USUniversity of Pennsylvania · US

Funding

Long-term Outcomes after Interventions for Congenital Heart DiseaseR01HL122392 · NHLBI · UNIVERSITY OF MINNESOTA · PI KOCHILAS, LAZAROS K. · 2014 to 2022
$5.2M
NHLBI NIH HHS R01 HL122392
6 · The paper itself

Abstract

This paper aims to update clinicians on "hot topics" in the management of patients with D-loop transposition of the great arteries (D-TGA) in the current surgical era. The arterial switch operation (ASO) has replaced atrial switch procedures for D-TGA, and 90% of patients now reach adulthood. The Adult Congenital and Pediatric Cardiology Council of the American College of Cardiology assembled a team of experts to summarize current knowledge on genetics, pre-natal diagnosis, surgical timing, balloon atrial septostomy, prostaglandin E1 therapy, intraoperative techniques, imaging, coronary obstruction, arrhythmias, sudden death, neoaortic regurgitation and dilation, neurodevelopmental (ND) issues, and lifelong care of D-TGA patients. In simple D-TGA: 1) familial recurrence risk is low; 2) children diagnosed pre-natally have improved cognitive skills compared with those diagnosed post-natally; 3) echocardiography helps to identify risk factors; 4) routine use of BAS and prostaglandin E1 may not be indicated in all cases; 5) early ASO improves outcomes and reduces costs with a low mortality; 6) single or intramural coronary arteries remain risk factors; 7) post-ASO arrhythmias and cardiac dysfunction should raise suspicion of coronary insufficiency; 8) coronary insufficiency and arrhythmias are rare but are associated with sudden death; 9) early- and late-onset ND abnormalities are common; 10) aortic regurgitation and aortic root dilation are well tolerated; and 11) the aging ASO patient may benefit from "exercise-prescription" rather than restriction. Significant strides have been made in understanding risk factors for cardiac, ND, and other important clinical outcomes after ASO.

Indexed as

Cardiac Surgical ProceduresHumansTransposition of Great VesselsVascular Surgical Proceduresadult congenital heart diseaseaortic dilationcongenital heart defectcongenital heart surgery and sequelaecoronary insufficiencyprostaglandin E

Identifiers

PMID25082585
PMCPMC4340094
OpenAlexW122418684

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.