ArticlePediatric diabetes2015
Assessing endothelial dysfunction in adolescents and young adults with type 1 diabetes mellitus using a non-invasive heat stimulus.
Article in Pediatric diabetes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Early Endothelial Dysfunction in Type 1 Diabetes Is Accompanied by an Impairment of Vascular Smooth Muscle Function: A Meta-Analysis.Frontiers in endocrinology · 2020Pooled it
- Cardiovascular and autonomic nervous system response to graded exercise in adolescents with type 1 diabetes.Frontiers in endocrinology · 2026Article
- Can Surrogate Markers Help Define Cardiovascular Disease in Youth?Current atherosclerosis reports · 2023Review
- Diabetes and climate change: current evidence and implications for people with diabetes, clinicians and policy stakeholders.Diabetologia · 2023Review
- The Endothelial Glycocalyx: Physiology and Pathology in Neonates, Infants and Children.Frontiers in cell and developmental biology · 2021Review
- Cardiac and Vascular Target Organ Damage in Pediatric Hypertension.Frontiers in pediatrics · 2018Article
- Assessing Microvascular Function in Humans from a Chronic Disease Perspective.Journal of the American Society of Nephrology : JASN · 2017Review
- Modifiable Risk Factors for Cardiovascular Disease in Children with Type 1 Diabetes: Can Early Intervention Prevent Future Cardiovascular Events?Current diabetes reports · 2017Review
- Endothelial Function and Arterial Stiffness Relate to Functional Outcomes in Adolescent and Young Adult Fontan Survivors.Journal of the American Heart Association · 2016Article
- Abnormalities of vascular structure and function in pediatric hypertension.Pediatric nephrology (Berlin, Germany) · 2016Review
- Arterial stiffness in adolescents and young adults with and without type 1 diabetes: the SEARCH CVD study.Pediatric diabetes · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMicrovascular dysfunction is a key event in the development of atherosclerosis, which predates the clinical manifestations of vascular disease including stroke and myocardial infarction. Dysfunction of the microvasculature can be measured as a decreased microperfusion in response to heat.
objectiveWe sought to evaluate the microvasculature using heat among adolescents and young adults with type 1 diabetes (T1D) compared to healthy non-diabetic controls. We hypothesized that youth with T1D would have impaired microvascular function measured as decreased perfusion.
methodsWe studied 181 adolescents and young adults with T1D and 96 age-, race-, and sex-matched healthy controls (mean age 19 yr). Patients were seen at an in-person study visit where demographics, anthropometrics, and laboratory data was obtained. Skin microvascular perfusion was measured on the volvar surface of the right forearm using a standard laser flow Doppler. Measurements were taken at baseline and after heating to 44° C.
resultsYouth with T1D had decreased microvascular perfusion as measured by lower percent change of perfusion units (1870 ± 945 vs. 2539 ± 1255, p < 0.01) and percent change in area under the curve (1870 ± 945 vs. 2539 ± 1255, p < 0.01) compared to controls. Glycosylated hemoglobin A1c (HbA1c) was found to be an independent determinant of microvascular function (p < 0.05).
conclusionsAdolescents and young adults with T1D have evidence of microvascular dysfunction that can be detected using heat, a non-invasive physiologic stimulus. HbA1c appears to play an independent role in determining microvascular perfusion suggesting tight glycemic control is probably important for the development of vascular disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.