ReviewNeuroscience bulletin2014
Activity-dependent signaling mechanisms regulating adult hippocampal neural stem cells and their progeny.
Review in Neuroscience bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer's disease.Stem cell research & therapy · 2024Article
- The expansion of newborn neurons in hippocampus improves social recognition deficit in a mouse model of autism.Frontiers in psychiatry · 2023Article
- The neurogenic niche in Alzheimer's disease.Neuroscience letters · 2021Review
- New Insights Into the Role of Aberrant Hippocampal Neurogenesis in Epilepsy.Frontiers in neurology · 2021Review
- Neurogenesis and Neuroplasticity in Major Depression: Its Therapeutic Implication.Advances in experimental medicine and biology · 2021Article
- Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches.eLife · 2020Article
- Treating Brain Disorders by Targeting Adult Neural Stem Cells.Trends in molecular medicine · 2018Review
- Neural mechanisms underlying GABAergic regulation of adult hippocampal neurogenesis.Cell and tissue research · 2018Review
- Brain-Derived Neurotrophic Factor Increases Synaptic Protein Levels via the MAPK/Erk Signaling Pathway and Nrf2/Trx Axis Following the Transplantation of Neural Stem Cells in a Rat Model of Traumatic Brain Injury.Neurochemical research · 2017Article
- Terminal Differentiation of Adult Hippocampal Progenitor Cells Is a Step Functionally Dissociable from Proliferation and Is Controlled by Tis21, Id3 and NeuroD2.Frontiers in cellular neuroscience · 2017Article
- Sonic Hedgehog Signaling and Hippocampal Neuroplasticity.Trends in neurosciences · 2016Review
- Phosphofructokinase-1 Negatively Regulates Neurogenesis from Neural Stem Cells.Neuroscience bulletin · 2016Article
- Lupus brain fog: a biologic perspective on cognitive impairment, depression, and fatigue in systemic lupus erythematosus.Immunologic research · 2015Review
- Astroglial β-Arrestin1-mediated Nuclear Signaling Regulates the Expansion of Neural Precursor Cells in Adult Hippocampus.Scientific reports · 2015Article
- Neurodevelopment and degeneration.Neuroscience bulletin · 2014Article
- Cholinergic Circuit Control of Postnatal Neurogenesis.Neurogenesis (Austin, Tex.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Adult neural stem cells (NSCs) reside in a restricted microenvironment, where their development is controlled by subtle and presently underexplored cues. This raises a significant question: what instructions must be provided by this supporting niche to regulate NSC development and functions? Signaling from the niche is proposed to control many aspects of NSC behavior, including balancing the quiescence and proliferation of NSCs, determining the cell division mode (symmetric versus asymmetric), and preventing premature depletion of stem cells to maintain neurogenesis throughout life. Interactions between neurogenic niches and NSCs also govern the homeostatic regulation of adult neurogenesis under diverse physiological, environmental, and pathological conditions. An important implication from revisiting many previously-identifi ed regulatory factors is that most of them (e.g., the antidepressant fluoxetine and exercise) affect gross neurogenesis by acting downstream of NSCs at the level of intermediate progenitors and neuroblasts, while leaving the NSC pool unaffected. Therefore, it is critically important to address how various niche components, signaling pathways, and environmental stimuli differentially regulate distinct stages of adult neurogenesis.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.