ArticleNature cell biology2014
Ovarian epithelium regeneration by Lgr5(+) cells.
Article in Nature cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- First report of telocytes in human ovarian stroma: an ultrastructural and immunohistochemical study.Histochemistry and cell biology · 2025Article
- LGR5: An emerging therapeutic target for cancer metastasis and chemotherapy resistance.Cancer metastasis reviews · 2025Review
- Identification and characterization of multipotential stem cells in immortalized normal ovarian surface epithelial cells.Acta biochimica et biophysica Sinica · 2024Article
- Single-cell transcriptome landscape of ovarian cells during primordial follicle assembly in mice.PLoS biology · 2020Article
- Dynamic expression patterns of Irx3 and Irx5 during germline nest breakdown and primordial follicle formation promote follicle survival in mouse ovaries.PLoS genetics · 2018Article
- Mechanisms controlling germline cyst breakdown and primordial follicle formation.Cellular and molecular life sciences : CMLS · 2017Review
- Novel population of small tumour-initiating stem cells in the ovaries of women with borderline ovarian cancer.Scientific reports · 2016Article
- Small putative NANOG, SOX2, and SSEA-4-positive stem cells resembling very small embryonic-like stem cells in sections of ovarian tissue in patients with ovarian cancer.Journal of ovarian research · 2016Article
- Ovulation: A consequence of acute inflammation cultivated by E2-induced reactive oxygen species and triggered by progesterone withdrawal.Tzu chi medical journalReview
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Lgr5, a marker of stem cells in many organs, is found expressed in cells scattered through the ovarian epithelium that expand to repair and regenerate the damaged ovarian surface after each ovulation. Lgr5-positive stem cells in the ovary and the fimbria of the oviduct may be critical cells of origin for ovarian cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.