ArticleReproductive biology and endocrinology : RB&E2014
Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life.
Article in Reproductive biology and endocrinology : RB&E, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- 4-phenylbutyric acid attenuates hepatic ER stress, pyroptosis, and NAFLD in adult rat offspring exposed to a high-fat, high-fructose diet during perinatal and adulthood.Lipids in health and disease · 2026Article
- Article
- Lifelong high-fat, high-sucrose diet causes sex-specific heart dysfunction in mouse offspring.Academia medicine · 2025Article
- Mismatch between obesogenic intrauterine environment and low-fat postnatal diet may confer offspring metabolic advantage.Obesity science & practice · 2021Article
- In utero exposure to maternal diabetes impairs nephron progenitor differentiation.American journal of physiology. Renal physiology · 2019Article
- Effect of Maternal Obesity and Preconceptional Weight Loss on Male and Female Offspring Metabolism and Olfactory Performance in Mice.Nutrients · 2019Article
- Transgenerational transmission of hedonic behaviors and metabolic phenotypes induced by maternal overnutrition.Translational psychiatry · 2018Article
- Maternal obesity increases the risk of metabolic disease and impacts renal health in offspring.Bioscience reports · 2018Review
- Article
- Enhanced sensitivity to drugs of abuse and palatable foods following maternal overnutrition.Translational psychiatry · 2016Article
- Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- From fatalism to mitigation: A conceptual framework for mitigating fetal programming of chronic disease by maternal obesity.Preventive medicine · 2015Review
- Developmental Programming: Priming Disease Susceptibility for Subsequent Generations.Current epidemiology reports · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMaternal overnutrition during pregnancy is associated with an increased risk of obesity and cardiometabolic disease in the offspring; a phenomenon attributed to 'developmental programming'. The post-weaning development of obesity may associate with exacerbation of the programmed metabolic phenotype. In mice, we have previously shown that exposure to maternal overnutrition causes increased weight gain in offspring before weaning, but exerts no persistent effects on weight or glucose tolerance in adulthood. In order to determine whether post-weaning exposure to a cafeteria diet might lead to an exacerbation of programmed effects, offspring born and raised by mothers on control (CON) or cafeteria (DIO) diets were transferred onto either CON or DIO diets at weaning.
findingsPost-weaning DIO caused the development of obesity, with hyperglycaemia and hyperinsulinaemia in males; and obesity with hyperinsulinaemia in females and with increased cholesterol levels in both sexes. Exposure to maternal overnutrition during pregnancy and lactation caused only subtle additional effects on offspring phenotype.
conclusionsThese results suggest that post-weaning exposure to a high-fat high-sugar diet has a more profound effect on offspring weight gain and glucose tolerance than exposure to maternal overnutrition. These data emphasise the importance of optimising early life nutrition in offspring of both obese and lean mothers.
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Registered trials
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