Evidence map›Paper›PMID 25081973›Full record

ReviewJournal of neuro-oncology2014

Stem cells and gliomas: past, present, and future.

Isabelle M Germano, Emanuela Binello

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neuro-oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Bionanotechnology and the future of glioma.Surgical neurology international · 2015
    Article
  7. Ephs and Ephrins in malignant gliomas.Growth factors (Chur, Switzerland) · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Isabelle M GermanoDepartment of Neurosurgery, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1136, New York, NY, 10029, USA, isabelle.germano@mountsinai.org.
Emanuela Binello

Funding

Transgenic in vivo delivery of MDA7/IL24 for maligannt glioma therapyR01CA129489 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GERMANO, ISABELLE M. · 2008 to 2012
$1.7M
NCI NIH HHS R01 CA1 129489-01A1NCI NIH HHS R01 CA129489
6 · The paper itself

Abstract

The recognition of stem cells (SC) in the adult CNS and in association with gliomas has spawned an entire field of research and intense investigation. A large body of knowledge is being accumulated to gain insight into the pathobiology of gliomas with the intent of finally improving the grave prognosis that continues to beset patients with high grade gliomas (HGG). In this article, we provide a historical overview of the events leading to the discovery of SC and glioma stem cells (GSC). We then focus on the current understanding of GSC with respect to markers, clinical significance, and their targeting. We discuss current data and developments using SC as vehicles to delivery therapeutic agents to HGG. We conclude with a discussion of opportunities for future development and concepts aimed at reducing tumor recurrence and improving survival for patients with HGG.

Indexed as

AnimalsBrain NeoplasmsCarcinogenesisClinical Trials as TopicGliomaHumansNeoplastic Stem CellsStem Cell Transplantation

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.