ArticleHernia : the journal of hernias and abdominal wall surgery2015
An experimental comparison of the effects of bacterial colonization on biologic and synthetic meshes.
Article in Hernia : the journal of hernias and abdominal wall surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of randomized controlled trials for the management of ventral hernia: biologic versus synthetic mesh.Updates in surgery · 2024Pooled it
- Histomorphometric Evaluation of the Tissue Response to Xenogeneic Extracellular Peritoneal Matrix and Synthetic UltraPro Mesh under Conditions of Pseudomonas aeruginosa Infection.Bulletin of experimental biology and medicine · 2026Article
- When helpful becomes harmful: a case-based narrative review of esophageal mesh migration after hiatal hernia repair.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2025Review
- Distinct impacts of aging on the immune responses to extracellular matrix-based versus synthetic biomaterials.Biomaterials · 2025Article
- Implant Infectious Diseases: An Introduction to Biomaterials for ID Physicians.Open forum infectious diseases · 2025Review
- Choice of Polymer, but Not Mesh Structure Variation, Reduces the Risk of Bacterial Infection withBiomedicines · 2023Article
- Hiatus hernia repair with a new-generation biosynthetic mesh: a 4-year single-center experience.Surgical endoscopy · 2023Article
- Outcomes of light and midweight synthetic mesh use in clean-contaminated and contaminated ventral incisional hernia repair: an ACHQC comparative analysis.Surgical endoscopy · 2023Article
- Article
- Article
- Biological Scaffolds for Abdominal Wall Repair: Future in Clinical Application?Materials (Basel, Switzerland) · 2019Review
- A critical review of the in vitro and in vivo models for the evaluation of anti-infective meshes.Hernia : the journal of hernias and abdominal wall surgery · 2018Review
- Characterization of host response, resorption, and strength properties, and performance in the presence of bacteria for fully absorbable biomaterials for soft tissue repair.Hernia : the journal of hernias and abdominal wall surgery · 2017Article
- Evaluation of a Novel Hybrid Viable Bioprosthetic Mesh in a Model of Mesh Infection.Plastic and reconstructive surgery. Global open · 2017Article
- Development of a novel murine model for treatment of infected mesh scenarios.Surgical endoscopy · 2017Article
- Commentary: Evidence for Replacement of an Infected Synthetic by a Biological Mesh in Abdominal Wall Hernia Repair.Frontiers in surgery · 2017Article
- Evaluation of a fully absorbable poly-4-hydroxybutyrate/absorbable barrier composite mesh in a porcine model of ventral hernia repair.Surgical endoscopy · 2016Article
- Bone Marrow-Derived Mesenchymal Stem Cells Enhance Bacterial Clearance and Preserve Bioprosthetic Integrity in a Model of Mesh Infection.Plastic and reconstructive surgery. Global open · 2016Article
- Bacterial adhesion to biological versus polymer prosthetic materials used in abdominal wall defect repair: do these meshes show any differences in vitro?Hernia : the journal of hernias and abdominal wall surgery · 2015Article
- Laparoscopic Ventral Hernia Repair with Poly-4-Hydroxybutyrate Absorbable Barrier Composite Mesh.JSLS : Journal of the Society of Laparoendoscopic SurgeonsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBiologic meshes are being used with increasing frequency to repair contaminated abdominal wall defects despite high long-term recurrence and infection rates associated with their use. Recent clinical reports describing the success of lightweight, macroporous synthetic meshes in contaminated ventral hernia repairs have led some surgeons to challenge the belief that synthetics are contraindicated in contaminated fields. We aimed to determine whether a frequently used biologic mesh (Strattice(TM)) is more resistant to bacterial colonization than macroporous synthetic mesh (Parietex(TM) Progrip(TM)) after inoculation with two common pathogens.
methodsRats (n = 48) were implanted subcutaneously with Strattice(TM) or Progrip(TM). Meshes were inoculated with sterile saline or a suspension containing 10(6) colony-forming units of Staphylococcus aureus or Escherichia coli prior to wound closure (n = 8 per subgroup). Meshes were explanted at 4 weeks and underwent microbiologic and histologic analyses.
resultsProgrip(TM) demonstrated superior bacterial clearance compared to Strattice(TM) (E. coli, 88 vs. 17% clearance, p = 0.03; S. aureus, 75 vs. 50%, p = 0.61; combined bacterial strains, 81 vs. 36%, p = 0.02; respectively). In the Strattice(TM) group, severely degraded meshes were observed in 100% of animals inoculated with E. coli (but 0% inoculated with S. aureus). In contrast, all Progrip(TM) meshes remained intact regardless of inoculum. Scores for neovascularization were higher in the synthetic group irrespective of contamination (p < 0.05).
conclusionsBiologic meshes may not be more resistant to bacterial colonization than reduced-weight synthetics, and their resistance may differ in response to different pathogens. The routine use of biologics in contaminated ventral hernia repair should be questioned, particularly in the presence of E. coli.
Indexed as
Identifiers
25081838What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.