Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2015
Comparing engage with PST in late-life major depression: a preliminary report.
Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Effectiveness of late-life depression interventions on functional limitations: A systematic review.International journal of mental health nursing · 2022Pooled it
- Comparing the streamlined psychotherapy "Engage" with problem-solving therapy in late-life major depression. A randomized clinical trial.Molecular psychiatry · 2021Trial
- A Pilot Randomized Trial of Engage Psychotherapy to Increase Social Connection and Reduce Suicide Risk in Later Life.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Trial
- Resting State Functional Connectivity and Outcomes of Psychotherapies for Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020Trial
- Engagement in Socially and Interpersonally Rewarding Activities as a Predictor of Outcome in "Engage" Behavioral Activation Therapy for Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019Trial
- Improving late life depression and cognitive control through the use of therapeutic video game technology: A proof-of-concept randomized trial.Depression and anxiety · 2017Trial
- Effects of Problem-Solving Therapy and Clinical Case Management on Disability in Low-Income Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2015Trial
- HCI Contributions in Mental Health: A Modular Framework to Guide Psychosocial Intervention Design.Proceedings of the SIGCHI conference on human factors in computing systems. CHI Conference · 2024Article
- Integrated smoking cessation and mood management following acute coronary syndrome: Protocol for the post-acute cardiac event smoking (PACES) trial.Addiction science & clinical practice · 2023Article
- A Pilot Study of Brief, Stepped Behavioral Activation for Primary Care Patients with Depressive Symptoms.Journal of clinical psychology in medical settings · 2023Article
- Mood and anxiety disorders within the Research Domain Criteria framework of Positive and Negative Valence Systems: a scoping review.Frontiers in human neuroscience · 2023Article
- Lessons learned from designing an asynchronous remote community approach for behavioral activation intervention for teens.Behaviour research and therapy · 2022Article
- Integrated Community Collaborative Care for Seniors with Depression/Anxiety and any Physical Illness.Canadian geriatrics journal : CGJ · 2021Article
- Leveraging human-centered design to implement modern psychological science: Return on an early investment.The American psychologist · 2020Review
- Community delivery of brief therapy for depressed older adults impacted by Hurricane Sandy.Translational behavioral medicine · 2020Article
- Use of Human-Centered Design to Improve Implementation of Evidence-Based Psychotherapies in Low-Resource Communities: Protocol for Studies Applying a Framework to Assess Usability .JMIR research protocols · 2019Article
- Mechanisms and treatment of late-life depression.Translational psychiatry · 2019Review
- Empirically supported interventions in psychology: contributions of Research Domain Criteria.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2019Review
- Perspectives on the Management of Vascular Depression.The American journal of psychiatry · 2018Review
- Reward learning impairment and avoidance and rumination responses at the end of Engage therapy of late-life depression.International journal of geriatric psychiatry · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe complexity of psychotherapies has been a barrier to community implementation. We used the Research Domain Criteria consensus as a guide to develop Engage, a streamlined, neurobiology-based psychotherapy for late-life depression that may match the skill set of practicing clinicians. This proof of concept study tested the hypotheses that Engage is bioequivalent to Problem Solving Therapy (PST) in reducing depressive symptoms, inducing remission, and ameliorating disability.
methodsEngage assumes that abnormal function of the positive valence systems fuels depression and uses "reward exposure" (engagement in meaningful, rewarding activities) as its principal intervention. Negativity bias, apathy, and emotional dysregulation are expressions of abnormalities in the negative valence, arousal and regulatory, and cognitive control systems, respectively. Engage targets each of them with simple interventions only if they interfere with reward exposure. We treated openly, with 9 weekly sessions of Engage, 39 older adults with unipolar major depression. We compared their course of depression (HAM-D), remission rate (HAM-D<10), and disability (WHODAS) with those of a historical comparison group (N = 97) treated with 9 weekly sessions of PST.
resultsCommunity social workers and research therapists required one third as much training time in Engage as in PST. Engage was non-inferior to PST in reducing HAM-D and WHODAS. Remission rates for Engage at 6 and 9 weeks were 18.2% and 41.1%, respectively. The corresponding figures for PST were 13.7% and 35.0%, respectively.
conclusionThese initial observations suggest that Engage has comparable efficacy with PST in reducing depressive symptoms and disability and warrants a randomized controlled trial.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.