Evidence map›Paper›PMID 25081634›Full record

ArticleSkeletal radiology2015

MR epidurography: distribution of injectate at caudal epidural injection.

Darra T Murphy, Eoin C Kavanagh, Ashley Poynton, Vikki O Chan, Michael R Moynagh, Stephen Eustace

Abstract readTechnical Report
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In one paragraph

Article in Skeletal radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Darra T MurphyCappagh National Orthopedic Hospital, Finglas, Dublin 11, Ireland, darramurphy@me.com.
Eoin C Kavanagh
Ashley Poynton
Vikki O Chan
Michael R Moynagh
Stephen Eustace

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo (a) evaluate the feasibility of MR epidurography (MRE) and (b) assess the distribution of injectate using two different volumes at caudal epidural steroid injection. MATERIALS AND

methodsTwenty patients who were referred with symptomatic low back pain for caudal epidural steroid injection were assigned to have either 10 ml (9/20) or 20 ml (11/20) of injectate administered. Gadolinium was included in the injection. The patients proceeded to MRI where sagittal and coronal T1-weighted fat-saturated sequences were acquired and reviewed in the mid-sagittal and right and left parasagittal views at the level of the exit foramina.

resultsGadolinium was observed at or above the L3/4 disc level in all 11 patients who received 20 ml (100 %), compared with only five of nine patients who received 10 ml (56 %). Injectate was seen to the L4 nerve root level in all 11 patients who received 20 ml (100 %) but only four out of nine patients who received 10 ml (44 %), not even reaching the L5 nerve root level in four further of these nine patients (44 %). Overall, there was a trend to visualize gadolinium at higher levels of the epidural space with higher volumes injected.

conclusionsFirstly, MR epidurography is a safe technique that allows excellent visualization of the distribution of gadolinium in the epidural space following injection via the caudal hiatus. Secondly, a volume of 10 ml is unlikely to treat L5/S1 disease in almost half of patients at caudal epidural steroid injection and at least 20 ml of injectate is likely required for any medication to reach the desired level.

Indexed as

AdultAgedAged, 80 and overAnti-Inflammatory AgentsContrast MediaDose-Response Relationship, DrugEpidural SpaceFeasibility StudiesFemaleGadolinium DTPAHumansImage EnhancementInjections, EpiduralLow Back PainMagnetic Resonance ImagingMaleAnti-Inflammatory AgentsContrast MediaGadolinium DTPAMethylprednisoloneMethylprednisolone Acetate

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.