Evidence map›Paper›PMID 25081619›Full record

ReviewProgress in molecular biology and translational science2014

Nuclear forces and cell mechanosensing.

Samer Alam, David B Lovett, Richard B Dickinson, Kyle J Roux, Tanmay P Lele

Abstract readReview
In one paragraph

Review in Progress in molecular biology and translational science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Review
  2. Article
  3. Vimentin - Force regulator in confined environments.Current opinion in cell biology · 2025
    Review
  4. Cellular and Nuclear Forces: An Overview.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Squishy matters - Corneal mechanobiology in health and disease.Progress in retinal and eye research · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Biochemistry · 2022
    Article
  14. Article
  15. Article
  16. Mechanical Studies of the Third Dimension in Cancer: From 2D to 3D Model.International journal of molecular sciences · 2021
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Samer AlamDepartment of Chemical Engineering, University of Florida, Gainesville, Florida, USA.
David B LovettDepartment of Chemical Engineering, University of Florida, Gainesville, Florida, USA.
Richard B DickinsonDepartment of Chemical Engineering, University of Florida, Gainesville, Florida, USA.
Kyle J RouxSanford Children's Health Research Center, University of South Dakota, Sioux Falls, South Dakota, USA.
Tanmay P LeleDepartment of Chemical Engineering, University of Florida, Gainesville, Florida, USA.

Funding

SUBSTRATE RIGIDITY AND GENE EXPRESSION: Role of Nuclear TensionR01EB014869 · NIBIB · UNIVERSITY OF FLORIDA · PI LELE, TANMAY P. · 2012 to 2019
$3.4M
Cytoskeletal force generation on the nucleusR01GM102486 · NIGMS · UNIVERSITY OF FLORIDA · PI LELE, TANMAY P. · 2012 to 2015
$1.2M
NIBIB NIH HHS 5R01EB014869-02NIBIB NIH HHS R01 EB014869NIGMS NIH HHS R01 GM102486NIGMS NIH HHS R01GM102486-01
6 · The paper itself

Abstract

Cells respond to mechanical signals, but the subcellular mechanisms are not well understood. The nucleus has recently emerged as an important mechanosensory organelle in the cell, as it is intimately connected to the cytoskeleton. Mechanical forces applied to cells that act on membrane-embedded receptors are transmitted through the cytoskeleton to the nuclear surface. Interfering with linkers of the nucleus to the cytoskeleton causes defects in cell mechanosensing and cell function. In this chapter, we discuss recent work in this area, highlighting the role that the nuclear linkages with the cytoskeleton play in cellular mechanotransduction.

Indexed as

Mechanotransduction, CellularAnimalsBiomechanical PhenomenaCell NucleusCytoskeletonHumansMultiprotein ComplexesMultiprotein ComplexesCytoskeletonKASH domain proteinsLamin A/CLINC complexMechanotransductionNesprin proteinsNuclear envelopeNucleusSUN domain proteins

Identifiers

PMID25081619
PMCPMC4261915

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.