ReviewProgress in molecular biology and translational science2014
The cellular mastermind(?)-mechanotransduction and the nucleus.
Review in Progress in molecular biology and translational science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Nuclear Wrinkles Result From Geometric Adaptations to Cellular and Nuclear Morphological Changes in Epithelial Cells.Genes to cells : devoted to molecular & cellular mechanisms · 2026Article
- A comparative study assessing neural recording quality and inflammatory tissue response between stiff and flexible microelectrode arrays.Biomaterials · 2026Article
- Article
- Unveiling the potential of biomechanics in pioneering innovative strategies for cancer therapy.Theranostics · 2025Review
- Increased H3K9me3 and F-Actin Reorganization in the Rapid Adaptive Response to Hypergravity in Human T Lymphocytes.International journal of molecular sciences · 2023Article
- Force transmission and SUN-KASH higher-order assembly in the LINC complex models.Biophysical journal · 2023Article
- Nucleus Mechanosensing in Cardiomyocytes.International journal of molecular sciences · 2023Review
- Elucidating the combinatorial effect of substrate stiffness and surface viscoelasticity on cellular phenotype.Journal of biomedical materials research. Part A · 2022Article
- Nuclear Lamins: Key Proteins for Embryonic Development.Biology · 2022Review
- Lamin microaggregates lead to altered mechanotransmission in progerin-expressing cells.Nucleus (Austin, Tex.) · 2020Article
- Cytoskeletal and nucleoskeletal interacting protein networks play critical roles in cellular function and dysfunction.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus.Molecular biology of the cell · 2017Article
- Review
- Squish and squeeze-the nucleus as a physical barrier during migration in confined environments.Current opinion in cell biology · 2016Review
- Integrin α4β1 controls G9a activity that regulates epigenetic changes and nuclear properties required for lymphocyte migration.Nucleic acids research · 2016Article
- Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- A Disulfide Bond Is Required for the Transmission of Forces through SUN-KASH Complexes.Biophysical journal · 2015Article
- Nuclear envelope: positioning nuclei and organizing synapses.Current opinion in cell biology · 2015Review
- Nuclear F-actin formation and reorganization upon cell spreading.The Journal of biological chemistry · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cells respond to mechanical stimulation by activation of specific signaling pathways and genes that allow the cell to adapt to its dynamic physical environment. How cells sense the various mechanical inputs and translate them into biochemical signals remains an area of active investigation. Recent reports suggest that the cell nucleus may be directly implicated in this cellular mechanotransduction process. Taken together, these findings paint a picture of the nucleus as a central hub in cellular mechanotransduction-both structurally and biochemically-with important implications in physiology and disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.