Evidence map›Paper›PMID 25081613›Full record

ReviewProgress in molecular biology and translational science2014

Single-cell imaging of mechanotransduction in endothelial cells.

Shaoying Lu, Yingxiao Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in molecular biology and translational science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Cortical Actin Dynamics in Endothelial Permeability.Current topics in membranes · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shaoying LuDepartment of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, California, USA.
Yingxiao WangDepartment of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, California, USA.

Funding

Role of Spatiotemporal Epigenetic Dynamics in Regulating Endothelial Gene Expressions under FlowsR01HL121365 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHIEN, SHU, WANG, YINGXIAO · 2014 to 2025
$7.5M
FRET Imaging of Molecular Hierarchy at Subcellular Levels in MechanotransductionR01HL098472 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI WANG, YINGXIAO · 2010 to 2014
$1.9M
The Integration of FLIM and FRET for the Visualization of Flow-induced MolecularK02HL109142 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI WANG, YINGXIAO · 2011 to 2015
$549k
The integration of FLIM with FRET biosensors for the sub-cellular visualization oR21CA139272 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI WANG, YINGXIAO · 2009 to 2010
$443k
A Systematic Approach to Engineer Fyn Kinase BiosensorR21GM106403 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, YINGXIAO · 2012 to 2013
$420k
NCI NIH HHS R21 CA139272NHLBI NIH HHS K02 HL109142NHLBI NIH HHS R01 HL098472NHLBI NIH HHS R01 HL121365NIGMS NIH HHS R21 GM106403
6 · The paper itself

Abstract

Endothelial cells (ECs) are constantly exposed to chemical and mechanical microenvironment in vivo. In mechanotransduction, cells can sense and translate the extracellular mechanical cues into intracellular biochemical signals, to regulate cellular processes. This regulation is crucial for many physiological functions, such as cell adhesion, migration, proliferation, and survival, as well as the progression of disease such as atherosclerosis. Here, we overview the current molecular understanding of mechanotransduction in ECs associated with atherosclerosis, especially those in response to physiological shear stress. The enabling technology of live-cell imaging has allowed the study of spatiotemporal molecular events and unprecedented understanding of intracellular signaling responses in mechanotransduction. Hence, we also introduce recent studies on mechanotransduction using single-cell imaging technologies.

Indexed as

Mechanotransduction, CellularAnimalsEndothelial CellsFocal AdhesionsHumansMolecular ImagingSingle-Cell AnalysisWound HealingEndothelial cellsMechanotransductionSingle cell imaging

Identifiers

PMID25081613
PMCPMC5665391

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.