ReviewAutonomic neuroscience : basic & clinical2014
Pathophysiology of neurally mediated syncope: Role of cardiac output and total peripheral resistance.
Review in Autonomic neuroscience : basic & clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Hyperoxia Improves Hemodynamic Status During Head-up Tilt Testing in Healthy Volunteers: A Randomized Study.Medicine · 2016Trial
- Article
- Differential engagement of inhibitory and excitatory cardiopulmonary reflexes by capsaicin and phenylbiguanide in C57BL/6 mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Calcitonin gene-related peptide predicts therapeutic response to midodrine hydrochloride in children with vasovagal syncope.Frontiers in neuroscience · 2022Article
- Assessment of cardiac function in syncopal children without organic causes.Clinical and experimental pediatrics · 2021Article
- Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation.Physiological reviews · 2021Review
- Towards Understanding the Genetic Nature of Vasovagal Syncope.International journal of molecular sciences · 2021Review
- Advance in the understanding of vasovagal syncope in children and adolescents.World journal of pediatrics : WJP · 2021Review
- Understanding vasovagal syncope: a role for sex and gender.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Article
- Pathophysiology and Individualized Management of Vasovagal Syncope and Postural Tachycardia Syndrome in Children and Adolescents: An Update.Neuroscience bulletin · 2020Review
- Autonomic uprising: the tilt table test in autonomic medicine.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Review
- Heart rate recovery and diastolic blood pressure ratio on the treadmill test predict an induction and recurrence of vasovagal syncope.The Korean journal of internal medicine · 2019Article
- Cardiac stroke volume variability measured non-invasively by three methods for detection of central hypovolemia in healthy humans.European journal of applied physiology · 2016Article
- Analysis of Heart Rate Variability Before and During Tilt Test in Patients with Cardioinhibitory Vasovagal Syncope.Arquivos brasileiros de cardiologia · 2016Article
- Mechanisms of orthostatic intolerance during heat stress.Autonomic neuroscience : basic & clinical · 2016Review
- The Current Indication for Pacemaker in Patients with Cardioinhibitory Vasovagal Syncope.The open cardiovascular medicine journal · 2016Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Syncope is a common clinical condition occurring even in otherwise healthy people without underlying cardiovascular disease. Neurally mediated syncope is by far the most common cause of syncope in individuals without any structural heart disease. Based on traditional wisdom, loss of sympathetic tone with relaxation of vascular smooth muscle is the key mechanism underlying the pathophysiology of syncope, especially in patients without an acute decrease in heart rate. However, this concept has recently been challenged. Some microneurographic studies indicate that sympathetic withdrawal may not always be a prerequisite even for the development of classic "vasodepressor" forms of syncope. Conversely, a decrease in cardiac output appears to be a determinant factor for syncope in most circumstances. This article reviews the relative contribution of cardiac output versus sympathetic vasoconstriction in neurally mediated syncope in otherwise healthy individuals. It is suggested that a moderate to severe fall in cardiac output with or without vasodilatation may contribute to syncope.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.