Evidence map›Paper›PMID 25081294›Full record

ArticleEye (London, England)2014

Visual function assessment in simulated real-life situations in patients with age-related macular degeneration compared to normal subjects.

G Barteselli, M L Gomez, A L Doede, J Chhablani, W Gutstein, D-U Bartsch, L Dustin, S P Azen, W R Freeman

Open access · bronzeAbstract readComparative Study

In one paragraph

Article in Eye (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it

0cells of the map it votes in

9citing papers in PubMed

1.1field-weighted citation impact, top 22% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

Dry eye disease treatment improves subjective quality-of-life responses in patients with AMD, independent of disease stage.PloS one · 2025
Article
The Effect of Age-Related Macular Degeneration on Components of Face Perception.Investigative ophthalmology & visual science · 2020
Article
Understanding the Impact of Individual Perceived Image Quality Features on Visual Performance.Translational vision science & technology · 2020
Article
Detecting vision loss in intermediate age-related macular degeneration: A comparison of visual function tests.PloS one · 2020
Article
ANATOMICAL AND FUNCTIONAL TESTING IN DIABETIC PATIENTS WITHOUT RETINOPATHY: Results of Optical Coherence Tomography Angiography and Visual Acuity Under Varying Contrast and Luminance Conditions.Retina (Philadelphia, Pa.) · 2019
Observational
Association of Cadmium and Lead Exposure With the Incidence of Contrast Sensitivity Impairment Among Middle-aged Adults.JAMA ophthalmology · 2018
Article
Improved retinal and visual function following panmacular subthreshold diode micropulse laser for retinitis pigmentosa.Eye (London, England) · 2018
Article
Impacts of impaired face perception on social interactions and quality of life in age-related macular degeneration: A qualitative study and new community resources.PloS one · 2018
Article
[Atrophy of the macula in the context of its wet, age-related degeneration : An inescapable consequence of anti-VEGF therapy?]Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2016
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

G Barteselli1] Department of Ophthalmology, Jacobs Retina Center at Shiley Eye Center, University of California, San Diego, La Jolla, CA, USA [2] Ophthalmological Unit, Department of Clinical Sciences and Community Health, Ca' Granda Foundation-Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.

M L GomezDepartment of Ophthalmology, Jacobs Retina Center at Shiley Eye Center, University of California, San Diego, La Jolla, CA, USA.

A L DoedeDepartment of Ophthalmology, Jacobs Retina Center at Shiley Eye Center, University of California, San Diego, La Jolla, CA, USA.

J ChhablaniL V Prasad Eye Institute, Hyderabad, India.

W GutsteinSalus University, Elkins Park, PA, USA.

D-U BartschDepartment of Ophthalmology, Jacobs Retina Center at Shiley Eye Center, University of California, San Diego, La Jolla, CA, USA.

L DustinDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

S P AzenDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

W R FreemanDepartment of Ophthalmology, Jacobs Retina Center at Shiley Eye Center, University of California, San Diego, La Jolla, CA, USA.

University of California, San Diego · USThe Retina Center · USUniversity of Southern California · USL V Prasad Eye Institute · INSalus University · US

Funding

Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Derek Stuart Welsbie · 2012 to 2026

$10.3M

TREATMENT OF RETINOPATHY ASSOCIATED WITH AIDSR01EY007366 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FREEMAN, WILLIAM R. · 1988 to 2013

$7.6M

Mechanistic-Based Non-Invasive Assessment of Retinal Damage in HAART EraR01EY016323 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BARTSCH, DIRK-UWE G · 2006 to 2020

$5.0M

Crystalline Antiproliferative Drugs for Intraocular DiseasesR01EY018589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FREEMAN, WILLIAM R. · 2008 to 2011

$2.0M

NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY007366NEI NIH HHS R01EY007366NEI NIH HHS R01 EY016323NEI NIH HHS R01EY016323NEI NIH HHS R01 EY018589NEI NIH HHS R01EY018589

6 · The paper itself

Abstract

purposeTo evaluate visual function variations in eyes with age-related macular degeneration (AMD) compared to normal eyes under different light/contrast conditions using a time-dependent visual acuity testing instrument, the Central Vision Analyzer (CVA).

methodsOverall, 37 AMD eyes and 35 normal eyes were consecutively tested with the CVA after assessing best-corrected visual acuity (BCVA) using ETDRS charts. The CVA established visual thresholds for three mesopic environments (M1 (high contrast), M2 (medium contrast), and M3 (low contrast)) and three backlight-glare environments (G1 (high contrast, equivalent to ETDRS), G2 (medium contrast), and G3 (low contrast)) under timed conditions. Vision drop across environments was calculated, and repeatability of visual scores was determined.

resultsBCVA significantly reduced with decreasing contrast in all eyes. M1 scores for BCVA were greater than M2 and M3 (P<0.001); G1 scores were greater than G2 and G3 (P<0.01). BCVA dropped more in AMD eyes than in normal eyes between M1 and M2 (P=0.002) and between M1 and M3 (P=0.003). In AMD eyes, BCVA was better using ETDRS charts compared to G1 (P<0.001). The drop in visual function between ETDRS and G1 was greater in AMD eyes compared to normal eyes (P=0.004). Standard deviations of test-retest ranged from 0.100 to 0.139 logMAR.

conclusionThe CVA allowed analysis of the visual complaints that AMD patients experience with different lighting/contrast time-dependent conditions. BCVA changed significantly under different lighting/contrast conditions in all eyes, however, AMD eyes were more affected by contrast reduction than normal eyes. In AMD eyes, timed conditions using the CVA led to worse BCVA compared to non-timed ETDRS charts.

Indexed as

AdultAgedAged, 80 and overContrast SensitivityFemaleGeographic AtrophyGlareHealthy VolunteersHumansLightMaleMesopic VisionMiddle AgedProspective StudiesReproducibility of ResultsVision Disorders

Identifiers

PMID25081294

DOI10.1038/eye.2014.189

PMCPMC4194345

OpenAlexW2063593908

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.