Evidence map›Paper›PMID 25081269›Full record

ArticleGenome announcements2014

Genome analysis of 17 extensively drug-resistant strains reveals new potential mutations for resistance.

H Guio, D Tarazona, M Galarza, V Borda, R Curitomay

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome announcements, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Collaborative Effort for a Centralized Worldwide Tuberculosis Relational Sequencing Data Platform.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

H Guiohguio@ins.gob.pe.
D TarazonaLaboratorio de Biotecnología y Biología Molecular, Instituto Nacional de Salud (INS), Lima, Peru.
M GalarzaLaboratorio de Biotecnología y Biología Molecular, Instituto Nacional de Salud (INS), Lima, Peru.
V BordaLaboratorio de Biotecnología y Biología Molecular, Instituto Nacional de Salud (INS), Lima, Peru.
R CuritomayDepartamento de Neumología, Hospital Nacional Hipólito Unanue, Lima, Peru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the whole-genome sequence of an extensively drug-resistant (XDR) tuberculosis (TB) strain of Latin American-Mediterranean (LAM) lineage. This strain is phenotypically resistant to aminoglycosides, but carries no related mutations in rrs, tlyA, and eis. Through genome analysis comparison with 16 XDR strains, we found 218 non-synonymous single nucleotide polymorphisms (SNPs) shared that could confer resistance.

Identifiers

PMID25081269
PMCPMC4118072

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.