ArticleInternational journal of behavioral medicine2015
The interaction of active substance use, depression, and antiretroviral adherence in methadone maintenance.
Article in International journal of behavioral medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Prevalence and predictors of medication non-adherence among people living with multimorbidity: a systematic review and meta-analysis.BMJ open · 2021Pooled it
- The effect of methadone on depression among addicts: a systematic review and meta-analysis.Health and quality of life outcomes · 2020Pooled it
- The Association Between Marijuana Use and HIV Continuum of Care Outcomes: a Systematic Review.Current HIV/AIDS reports · 2019Pooled it
- Cannabis use patterns among people with HIV before and after legalization.Drug and alcohol dependence reports · 2024Article
- Self-Reported Cannabis Use and HIV Viral Control among Patients with HIV Engaged in Care: Results from a National Cohort Study.International journal of environmental research and public health · 2022Article
- Polysubstance use and adherence to antiretroviral treatment in the Miami Adult Studies on HIV (MASH) cohort.AIDS care · 2022Article
- Marijuana use and viral suppression in persons receiving medical care for HIV-infection.The American journal of drug and alcohol abuse · 2017Article
- Association between cannabis use and treatment outcomes in patients receiving methadone maintenance treatment: a systematic review protocol.Systematic reviews · 2016Article
- Medication adherence in people dually treated for HIV infection and mental health conditions: test of the medications beliefs framework.Journal of behavioral medicine · 2015Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAdherence to highly active antiretroviral therapy (HAART) remains crucial in successfully treating HIV. While active substance use and depression are both associated with each other and with HAART nonadherence, little is known about their interaction. An understanding of the interaction of substance use and depressive symptoms on HAART adherence can inform adherence-enhancing interventions as well as interventions that target substance use and depression. PURPOSE: We tested an interaction between substance use and depression on HAART adherence among methadone maintenance patients.
methodWe assessed substance use, depressive symptoms, and HAART adherence among 100 HIV-infected individuals receiving methadone maintenance in The Bronx, New York. Regressions were performed on adherence using an interaction term comprised of substance use and depressive symptoms. MODPROBE was used to assess significant interactions.
resultsAny use of illicit substances was associated with HAART nonadherence (p = 0.043). Cannabis was the single substance of abuse most strongly associated with nonadherence (p = 0.003). Depressive symptoms approached significance in bivariate analysis (p = 0.066). In regression analysis, a significant interaction was found between illicit substance use and depressive symptoms [OR (95% CI) 1.23 (1.06-1.44), p = 0.007], where illicit substance use was associated with nonadherence in individuals with lower depressive symptoms, but not among those with depressive symptoms at higher levels. No individual substances interacted with depressive symptoms on adherence.
conclusionThough substance use and depressive symptoms interacted on HAART adherence, they did not have a synergistic effect. Continued substance use (51% of the sample) suggests an unmet need for treatment, even in methadone maintenance. Further examinations of the interplay of substance use and depression on HAART adherence are warranted.
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