ReviewClinical reviews in allergy & immunology2015
Current Approach to Dry Eye Disease.
Review in Clinical reviews in allergy & immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Variations of dry eye disease prevalence by age, sex and geographic characteristics in China: a systematic review and meta-analysis.Journal of global health · 2018Pooled it
- Sex hormone therapy's effect on dry eye syndrome in postmenopausal women: A meta-analysis of randomized controlled trials.Medicine · 2018Pooled it
- A systematic review of non-pharmacological interventions for primary Sjögren's syndrome.Rheumatology (Oxford, England) · 2015Pooled it
- Corneal epithelial thickness can reflect the stage of Parkinson's disease and the severity of dry eye.Frontiers in aging neuroscience · 2026Article
- Diagnostic methods for managing dry eyes.World journal of methodology · 2025Article
- Oculoplastic Interventions in the Management of Ocular Surface Diseases: A Comprehensive Review.Life (Basel, Switzerland) · 2025Review
- Review
- Dry eye in Parkinson's disease: a narrative review.Frontiers in neurology · 2023Review
- Protective effect of Tisochrysis lutea on dry eye syndrome via NF-κB inhibition.Scientific reports · 2022Article
- Safety and efficacy of pilocarpine, cevimeline, and diquafosol compared to artificial tears for the treatment of dry eye: protocol for a systematic review.Systematic reviews · 2022Article
- Oxytocin and secretin receptors - implications for dry eye syndrome and ocular pain.Frontiers in ophthalmology · 2022Review
- Tacrolimus Loaded Cationic Liposomes for Dry Eye Treatment.Frontiers in pharmacology · 2022Article
- Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives.Journal of ophthalmology · 2022Review
- Applications of Hyaluronic Acid in Ophthalmology and Contact Lenses.Molecules (Basel, Switzerland) · 2021Review
- Systemic diseases and the cornea.Experimental eye research · 2021Review
- A Set of Global Metabolomic Biomarker Candidates to Predict the Risk of Dry Eye Disease.Frontiers in cell and developmental biology · 2020Article
- Systemic lupus erythematosus and ocular involvement: an overview.Clinical and experimental medicine · 2018Review
- Article
- Tear Ferning Test and Pathological Effects on Ocular Surface before and after Topical Cyclosporine in Vernal Keratoconjunctivitis Patients.Journal of ophthalmology · 2018Article
- Development ofThe open ophthalmology journal · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dry eye disease (DED) is a multifactorial disease of the tears and ocular surface that causes tear film instability with potential damage to the ocular surface. The prevalence of dry eye in the world population ranges from 6 to 34 %. It is more common in those aged over 50, and affects mainly women. Since the introduction of the Schirmer's test in 1903, other tests have been developed to evaluate dry eye, such as biomicroscopy, the tear film breakup time (BUT), vital dyes (lissamine green and rose bengal), fluorescein, leaf fern test, corneal sensitivity test, conjunctiva impression cytology, optical coherence tomography (OCT), and tear osmolarity measurement. Although there is no gold standard, it is advisable to combine at least two tests. Strategies for treating DED have recently been modified and include patient education, tear substitute, corticosteroids, secretagogues, fatty acids, immunomodulators, occlusion of lacrimal puncta surgery and, tarsorrhaphy. Biological therapy and new topical immunomodulators such as tacrolimus, tofacitinib and IL-1 receptor inhibitor are being tested. In this review, the evaluation tests for dry eye are compared and the main studies on treatment are presented, with emphasis on studies in patients with Sjögren's syndrome. The authors propose an approach for the management of dry eye.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.