ArticleAsian journal of andrology
Meiotic abnormalities in metaphase I human spermatocytes from infertile males: frequencies, chromosomes involved, and the relationships with polymorphic karyotype and seminal parameters.
Article in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- The forbidden doubling: exploring rare spermatocyte polyploidy in mammals.Comparative cytogenetics · 2026Article
- Recessive dystrophic epidermolysis bullosa caused by a novel COL7A1 variant with isodisomy.Human genome variation · 2023Article
- Article
- Parental chromosomal heteromorphisms are not associated with an increased risk of embryo aneuploidy.JBRA assisted reproduction · 2021Article
- Therapeutic Dose of Hydroxyurea-Induced Synaptic Abnormalities on the Mouse Spermatocyte.Frontiers in physiology · 2021Article
- Male infertility: establishing sperm aneuploidy thresholds in the laboratory.Journal of assisted reproduction and genetics · 2019Review
- Altered bivalent positioning in metaphase I human spermatocytes from Robertsonian translocation carriers.Journal of assisted reproduction and genetics · 2017Article
- Is number of chiasmata an etiological factor of male infertility?Asian journal of andrologyArticle
- Unpaired sex chromosomes in metaphase I human spermatocytes locally modify autosomal bivalents positioning.Asian journal of andrologyArticle
- A comprehensive analysis of chromosomal anomalies in metaphase II spermatocytes from infertile patients.Asian journal of andrologyArticle
- Re: Is number of chiasmata an etiological factor of male infertility?Asian journal of andrologyArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to look in depth at the relationship between meiotic anomalies and male infertility, such as the determination of the chromosomes involved or the correlation with patient features. For this purpose, a total of 31 testicular tissue samples from individuals consulting for fertility problems were analyzed. Metaphase I cells were evaluated using a sequential methodology combining Leishman stained procedures and multiplex fluorescence in situ hybridization protocols. The number of chromosomal units and chiasmata count per bivalent were established and a hierarchical cluster analysis of the individuals was performed. The relationship of the seminogram and the karyotype over recombination were evaluated using Poisson regression models. Results obtained in this study show a significant percentage of infertile individuals with altered meiotic behavior, mostly specified as a reduction in chiasmata count in medium and large chromosomes, the presence of univalents, and the observation of tetraploid metaphases. Moreover, the number and the type of anomalies were found to be different between cells of the same individual, suggesting the coexistence of cell lines with normal meiotic behavior and cell lines with abnormalities. In addition, chromosomal abnormalities in metaphase I are significantly associated with oligozoospermia and/or polymorphic karyotype variants.
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Registered trials
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