ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
Lung ventilation injures areas with discrete alveolar flooding, in a surface tension-dependent fashion.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Acinar micromechanics in health and lung injury: what we have learned from quantitative morphology.Frontiers in physiology · 2023Review
- Lung Ultrasound Induction of Pulmonary Capillary Hemorrhage in Neonatal Swine.Ultrasound in medicine & biology · 2022Article
- Perioperative Pulmonary Atelectasis: Part I. Biology and Mechanisms.Anesthesiology · 2022Review
- Intravenous sulforhodamine B reduces alveolar surface tension, improves oxygenation, and reduces ventilation injury in a respiratory distress model.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Neutrophil-Derived IL-17 Promotes Ventilator-Induced Lung InjuryFrontiers in immunology · 2021Article
- Sulforhodamine B and exogenous surfactant effects on alveolar surface tension under acute respiratory distress syndrome conditions.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Mechanical Ventilation Lessons Learned From Alveolar Micromechanics.Frontiers in physiology · 2020Review
- Hidden Microatelectases Increase Vulnerability to Ventilation-Induced Lung Injury.Frontiers in physiology · 2020Article
- The Contribution of Surface Tension-Dependent Alveolar Septal Stress Concentrations to Ventilation-Induced Lung Injury in the Acute Respiratory Distress Syndrome.Frontiers in physiology · 2020Article
- Surfactant Protein B Deficiency Induced High Surface Tension: Relationship between Alveolar Micromechanics, Alveolar Fluid Properties and Alveolar Epithelial Cell Injury.International journal of molecular sciences · 2019Article
- The micromechanics of lung alveoli: structure and function of surfactant and tissue components.Histochemistry and cell biology · 2018Review
- Tracheal acid or surfactant instillation raises alveolar surface tension.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Ventilator-induced lung injury and lung mechanics.Annals of translational medicine · 2018Review
- Linking lung function to structural damage of alveolar epithelium in ventilator-induced lung injury.Respiratory physiology & neurobiology · 2018Article
- Tidal changes on CT and progression of ARDS.Thorax · 2017Article
- Accelerated deflation promotes homogeneous airspace liquid distribution in the edematous lung.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Linking Ventilator Injury-Induced Leak across the Blood-Gas Barrier to Derangements in Murine Lung Function.Frontiers in physiology · 2017Article
- Strain heterogeneity in the injured lung: cause or consequence?Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Conservative fluid management prevents age-associated ventilator induced mortality.Experimental gerontology · 2016Article
- Mild loss of lung aeration augments stretch in healthy lung regions.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
With proteinaceous-liquid flooding of discrete alveoli, a model of the edema pattern in the acute respiratory distress syndrome, lung inflation over expands aerated alveoli adjacent to flooded alveoli. Theoretical considerations suggest that the overexpansion may be proportional to surface tension, T. Yet recent evidence indicates proteinaceous edema liquid may not elevate T. Thus whether the overexpansion is injurious is not known. Here, working in the isolated, perfused rat lung, we quantify fluorescence movement from the vasculature to the alveolar liquid phase as a measure of overdistension injury to the alveolar-capillary barrier. We label the perfusate with fluorescence; micropuncture a surface alveolus and instill a controlled volume of nonfluorescent liquid to obtain a micropunctured-but-aerated region (control group) or a region with discrete alveolar flooding; image the region at a constant transpulmonary pressure of 5 cmH2O; apply five ventilation cycles with a positive end-expiratory pressure of 0-20 cmH2O and tidal volume of 6 or 12 ml/kg; return the lung to a constant transpulmonary pressure of 5 cmH2O; and image for an additional 10 min. In aerated areas, ventilation is not injurious. With discrete alveolar flooding, all ventilation protocols cause sustained injury. Greater positive end-expiratory pressure or tidal volume increases injury. Furthermore, we determine T and find injury increases with T. Inclusion of either plasma proteins or Survanta in the flooding liquid does not alter T or injury. Inclusion of 2.7-10% albumin and 1% Survanta together, however, lowers T and injury. Contrary to expectation, albumin inclusion in our model facilitates exogenous surfactant activity.
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