ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Arc visualization of odor objects reveals experience-dependent ensemble sharpening, separation, and merging in anterior piriform cortex in adult rat.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- The Role of the Stimulus in Olfactory Plasticity.Brain sciences · 2023Review
- Effects of stochastic coding on olfactory discrimination in flies and mice.PLoS biology · 2023Article
- Experience-dependent evolution of odor mixture representations in piriform cortex.PLoS biology · 2023Article
- Understanding Categorical Learning in Neural Circuits Through the Primary Olfactory Cortex.Frontiers in cellular neuroscience · 2022Article
- Cortical feedback and gating in odor discrimination and generalization.PLoS computational biology · 2021Article
- Locus Coeruleus Activation Patterns Differentially Modulate Odor Discrimination Learning and Odor Valence in Rats.Cerebral cortex communications · 2021Article
- Novelty-like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress-inducing activation worsens its effects.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- Odor coding in piriform cortex: mechanistic insights into distributed coding.Current opinion in neurobiology · 2020Review
- Article
- An experimental model of Braak's pretangle proposal for the origin of Alzheimer's disease: the role of locus coeruleus in early symptom development.Alzheimer's research & therapy · 2019Article
- Pheromone-Induced Odor Associative Fear Learning in Rats.Scientific reports · 2018Article
- Article
- Article
- Arc-Expressing Neuronal Ensembles Supporting Pattern Separation Require Adrenergic Activity in Anterior Piriform Cortex: An Exploration of Neural Constraints on Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Coding of odor stimulus features among secondary olfactory structures.Journal of neurophysiology · 2015Article
- Lack of spatial segregation in the representation of pheromones and kairomones in the mouse medial amygdala.Frontiers in neuroscience · 2015Article
- Computational modeling suggests distinct, location-specific function of norepinephrine in olfactory bulb and piriform cortex.Frontiers in computational neuroscience · 2015Article
- Visualizing the engram: learning stabilizes odor representations in the olfactory network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Learning modulation of odor representations: new findings from Arc-indexed networks.Frontiers in cellular neuroscience · 2014Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
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Abstract
Visualization using the immediate early gene Arc revealed sparser and more robust odor representations in the anterior piriform cortex of adult rats when odor was associated with water reward over 2-3 d. Rewarded odor "mixtures" resulted in rats responding to either component odor similarly, and, correspondingly, the odor representations became more similar as indexed by increased overlap in piriform Arc-expressing (Arc(+)) pyramidal neurons. The increased overlap was consistent with the rats' generalization from component odors. Discriminating among highly similar odor mixtures for reward led to increased differentiation of the neural representations as indexed by a reduction in overlap for piriform Arc(+) pyramidal neurons after training. Similar odor mixture discrimination also required more trials to criterion. The visible reduction in the overlap of odor representations indexes pattern separation. The Arc visualization of odor representations in the anterior piriform network suggests that odor objects are widely distributed representations and can be rapidly modified by reward training in adult rats. We suggest that dynamic changes such as those observed here in piriform odor encoding are at the heart of perceptual learning and reflect the continuing plastic nature of mature associative cortex as an outcome of successful problem solving.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.