ArticleJournal of neurophysiology2014
Electrical synaptic transmission in developing zebrafish: properties and molecular composition of gap junctions at a central auditory synapse.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Defining the electrical synapse.Nature reviews. Neuroscience · 2026Review
- Expansion microscopy reveals neural circuit organization in genetic animal models.Neurophotonics · 2025Review
- The components of an electrical synapse as revealed by expansion microscopy of a single synaptic contact.eLife · 2024Article
- Electrical synapse structure requires distinct isoforms of a postsynaptic scaffold.PLoS genetics · 2023Article
- The Nature and Origin of Synaptic Inputs to Vestibulospinal Neurons in the Larval Zebrafish.eNeuro · 2023Article
- Neurobeachin controls the asymmetric subcellular distribution of electrical synapse proteins.Current biology : CB · 2023Article
- The nature and origin of synaptic inputs to vestibulospinal neurons in the larval zebrafish.bioRxiv : the preprint server for biology · 2023Article
- The calcium-sensing receptor (CaSR) regulates zebrafish sensorimotor decision making via a genetically defined cluster of hindbrain neurons.Cell reports · 2022Article
- ThemicroPublication biology · 2022Article
- A forward genetic screen identifies Dolk as a regulator of startle magnitude through the potassium channel subunit Kv1.1.PLoS genetics · 2021Article
- Article
- Acute Regulation of Habituation Learning via Posttranslational Palmitoylation.Current biology : CB · 2020Article
- Understanding the Molecular and Cell Biological Mechanisms of Electrical Synapse Formation.Frontiers in neuroanatomy · 2020Article
- Effects of Constitutive and Acute Connexin 36 Deficiency on Brain-Wide Susceptibility to PTZ-Induced Neuronal Hyperactivity.Frontiers in molecular neuroscience · 2020Article
- Prepontine non-giant neurons drive flexible escape behavior in zebrafish.PLoS biology · 2019Article
- Human Inner Ear Immune Activity: A Super-Resolution Immunohistochemistry Study.Frontiers in neurology · 2019Article
- Presynaptic Inhibition Selectively Gates Auditory Transmission to the Brainstem Startle Circuit.Current biology : CB · 2018Article
- A Cyfip2-Dependent Excitatory Interneuron Pathway Establishes the Innate Startle Threshold.Cell reports · 2018Article
- Asymmetry of an Intracellular Scaffold at Vertebrate Electrical Synapses.Current biology : CB · 2017Article
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9 authors at 2 institutions in 1 country.
Funding
Abstract
In contrast to the knowledge of chemical synapses, little is known regarding the properties of gap junction-mediated electrical synapses in developing zebrafish, which provide a valuable model to study neural function at the systems level. Identifiable "mixed" (electrical and chemical) auditory synaptic contacts known as "club endings" on Mauthner cells (2 large reticulospinal neurons involved in tail-flip escape responses) allow exploration of electrical transmission in fish. Here, we show that paralleling the development of auditory responses, electrical synapses at these contacts become anatomically identifiable at day 3 postfertilization, reaching a number of ∼6 between days 4 and 9. Furthermore, each terminal contains ∼18 gap junctions, representing between 2,000 and 3,000 connexon channels formed by the teleost homologs of mammalian connexin 36. Electrophysiological recordings revealed that gap junctions at each of these contacts are functional and that synaptic transmission has properties that are comparable with those of adult fish. Thus a surprisingly small number of mixed synapses are responsible for the acquisition of auditory responses by the Mauthner cells, and these are likely sufficient to support escape behaviors at early developmental stages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.