Evidence map›Paper›PMID 25080503›Full record

SynthesisHuman molecular genetics2014

Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.

Johnny S H Kwan, Yi-Hsiang Hsu, Ching-Lung Cheung, Josée Dupuis, Aude Saint-Pierre, Joel Eriksson, Samuel K Handelman, Aaron Aragaki, David Karasik, Peter P Pramstaller and 15 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human molecular genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 13 institutions in 6 countries.

Johnny S H KwanDepartment of Medicine, Department of Psychiatry and.
Yi-Hsiang HsuInstitute for Aging Research, Hebrew SeniorLife, Boston, MA, USA, Program of Quantitative Genomics, Harvard School of Public Health, Boston, MA, USA, BROAD Institute of the MIT and Harvard, Cambridge, MA, USA.
Ching-Lung CheungDepartment of Medicine.
Josée DupuisFramingham Heart Study of the National, Heart, Lung, and Blood Institute and Boston University, Framingham, MA, USA, Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Aude Saint-PierreCenter for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany, INSERM U1078, Etablissement Français du Sang, Brest, France.
Joel ErikssonCentre for Bone and Arthritis Research, Departments of Internal Medicine and Geriatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Samuel K HandelmanDepartment of Pharmacology and.
Aaron AragakiDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, The Ohio State University, Columbus, OH, USA.
David KarasikInstitute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Peter P PramstallerCenter for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany, Department of Neurology, General Central Hospital, Bolzano, Italy, Department of Neurology, University of Lübeck, Lübeck, Germany.
Charles KooperbergFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Andrea Z LacroixDepartment of Preventive Medicine, University of California San Diego, San Diego, CA, USA.
Martin G LarsonFramingham Heart Study of the National, Heart, Lung, and Blood Institute and Boston University, Framingham, MA, USA, Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Kam-Shing LauDepartment of Medicine.
Mattias LorentzonCentre for Bone and Arthritis Research, Departments of Internal Medicine and Geriatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Irene PichlerCenter for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany.
Pak C ShamDepartment of Psychiatry and Centre for Genomic Sciences, University of Hong Kong, Pokfulam, Hong Kong.
Daniel TaliunCenter for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany.
Liesbeth VandenputCentre for Bone and Arthritis Research, Departments of Internal Medicine and Geriatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Douglas P KielInstitute for Aging Research, Hebrew SeniorLife, Boston, MA, USA, BROAD Institute of the MIT and Harvard, Cambridge, MA, USA, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Andrew A HicksCenter for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany.
Rebecca D JacksonDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, The Ohio State University, Columbus, OH, USA.
Claes OhlssonCentre for Bone and Arthritis Research, Departments of Internal Medicine and Geriatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Emelia J BenjaminFramingham Heart Study of the National, Heart, Lung, and Blood Institute and Boston University, Framingham, MA, USA, Department of Medicine, Boston University School of Medicine, Boston, MA, USA and.
Annie W C KungDepartment of Medicine, awckung@hkucc.hku.hk.
University of Gothenburg · SEBoston University · USEurac Research · ITThe Ohio State University · USUniversity of Lübeck · DEBeth Israel Deaconess Medical Center · USBroad Institute · USFred Hutch Cancer Center · USHebrew SeniorLife · USNational Heart Lung and Blood Institute · USOspedale di Bolzano · ITUniversity of California, San Diego · USUniversity of Hong Kong · HK

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
RISK FACTORS FOR VERTEBRAL FRACTURE AND BONE LOSSR01AR041398 · NIAMS · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI KIEL, DOUGLAS P. · 1991 to 2025
$16.1M
Expression Genetics in Drug TherapyU01GM092655 · NIGMS · OHIO STATE UNIVERSITY · PI SADEE, WOLFGANG · 2010 to 2014
$8.6M
Framingham: Inflammation, Genes &Cardiovascular DiseaseR01HL076784 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2004 to 2008
$3.9M
Aging and Inflammation: Longitudinal Markers and Genetics in the Framingham StudyR01AG028321 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2006 to 2010
$1.8M
INFLAMMATION: CORRELATES AND PROGNOSIS IN FRAMINGHAMR01HL064753 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2000 to 2003
$1.2M
SLEEP AND ENTRAINMENT OF SCN FUNCTIONR01HL064278 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI STROHL, KINGMAN PERKINS · 1999 to 2002
$871k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NCI NIH HHS P30 CA015704NCRR NIH HHS U54RR0024384NHLBI NIH HHS 1R01HL64753NHLBI NIH HHS 2R01HL092577NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01-HC-25195NHLBI NIH HHS N02-HL-6-4278NHLBI NIH HHS R01 HL076784NHLBI NIH HHS R01HL076784NHLBI NIH HHS R01 HL092577NIAMS NIH HHS R01 AR041398NIA NIH HHS 1 R01AG028321NIA NIH HHS R01 AG028321NIA NIH HHS R01AR/AG 41398NIGMS NIH HHS U01 GM092655NIGMS NIH HHS U01GM092655
6 · The paper itself

Abstract

Osteoprotegerin (OPG) is involved in bone homeostasis and tumor cell survival. Circulating OPG levels are also important biomarkers of various clinical traits, such as cancers and atherosclerosis. OPG levels were measured in serum or in plasma. In a meta-analysis of genome-wide association studies in up to 10 336 individuals from European and Asian origin, we discovered that variants >100 kb upstream of the TNFRSF11B gene encoding OPG and another new locus on chromosome 17q11.2 were significantly associated with OPG variation. We also identified a suggestive locus on chromosome 14q21.2 associated with the trait. Moreover, we estimated that over half of the heritability of OPG levels could be explained by all variants examined in our study. Our findings provide further insight into the genetic regulation of circulating OPG levels.

Indexed as

Genetic LociPolymorphism, GeneticQuantitative Trait, HeritableAsian PeopleChromosomes, Human, Pair 14Chromosomes, Human, Pair 17FemaleGenome, HumanGenome-Wide Association StudyHumansMaleOsteoprotegerinWhite PeopleOsteoprotegerinTNFRSF11B protein, human

Identifiers

PMID25080503
PMCPMC4240210
OpenAlexW2149501497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.